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palmitoylethanolamide cbd

Palmitoylethanolamide cbd

5 Campos AC, Foga.a MV, Sonego AB, Guimar.es FS. Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res, vol. 112, pp.119–127, 2016. ​

1 Hartsel JA, Eades J, Hickory B, Makriyannis A.Cannabis sativa and Hemp. Nutraceuticals: Efficacy, Safety and Toxicity, pp. 735–754, 2016. ​

20 David Briskey, Georgia Roche, Amanda Rao. The Effect of a Dispersible Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Joint Pain in an Adult Population – A Randomised, Double-Blind Study. International Journal of Nutrition and Food Sciences. Vol. 10, No. 1, 2021, pp. 9-13. doi: 10.11648/j.ijnfs.20211001.12 ​

PEA and the ECS

Because of its fatty nature, PEA has trouble dissolving in water which causes a drastic reduction with both bioavailability and absorption inside the body’s digestive system. To overcome the challenge, Gencor utilized the novel, award-winning LipiSperse delivery technology, created by Pharmako Biotechnologies to develop a branded form of PEA named Levagen+, which significantly increases both the bioavailability and functionality of PEA.

In a recently published study​ in the International Journal of Nutrition and Food Sciences, ​the study assessed the efficacy of dispersible Palmitoylethanolamide – PEA (Levagen+) for alleviating joint discomfort and improving quality of life in adults.

Levagen+ PEA has been studied to provided targeted benefits for joint health, sports recovery, inflammation, relaxation and sleep.

CBD and the ECS

Recent research has shown that PEA, similar to CBD, can influence the endocannabinoid system. Unlike CBD, PEA is structurally related to the bliss molecule, and because of this, it may co-enhance AEAs effects as well as inhibit FAAH. 13 ​ PEA also works both directly and indirectly within the central and peripheral nervous systems. Directly, PEA reduces inflammation locally by halting the activity of pro-inflammatory genes and the production of many inflammatory substances via PPAR-α receptors. 14 ​ Indirectly, PEA enhances the levels and actions of other compounds (e.g. AEA) that are anti-inflammatory and provide analgesic relief. This mechanism is known as the ‘entourage effect’. 14 ​ AEA’s ability to bind on to both CB receptors and TRPV-1 channels helps combat inflammation and increase relaxation.

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15 Hesselink, J.M.K. (2012). New targets in pain, nonneuronal cells, and the role of palmitoylethanolamide. The Open Pain Journal, 5, 12-23. ​

Cannabinoids (CBs) have recently been approved to exert broad anti-inflammatory activities in experimental models of multiple sclerosis (MS). It has been demonstrated that these compounds could also have effects on neurodegeneration, demyelination, and autoimmune processes occurring in the pathology of MS. However, the clinical use of CBs is limited by their psychoactive effects. Among cannabinoid compounds, cannabidiol (CBD) and palmitoylethanolamide (PEA) have no psychotropic activities. We induced experimental autoimmune encephalomyelitis (EAE), a model of MS, by injecting myelin oligodendrocyte glycoprotein (MOG) to C57BL/6 mice. We assessed the effects of CBD, PEA, and co-administration of CBD and PEA on neurobehavioral scores, immune cell infiltration, demyelination, axonal injury, and the expression of inflammatory cytokines by using histochemistry methods and real-time RT-PCR. Treatment with either CBD (5mg/kg) or PEA (5mg/kg) during disease onset reduced the severity of the neurobehavioral scores of EAE. This effect of CBD and PEA was accompanied by diminished inflammation, demyelination, axonal damage and inflammatory cytokine expression while concurrent administration of CBD (5mg/kg) and PEA (5mg/kg) was not as effective as treatment with either drug per se. These results suggest that, CBD and PEA, non-psychoactive CBs, attenuate neurobehavioral deficits, histological damage, and inflammatory cytokine expression in MOG-immunized animals. However, there is an antagonistic interaction between CBD and PEA in protection against MOG-induced disease.

Keywords: EAE; cannabidiol; cannabinoid; multiple sclerosis; palmitoylethanolamide.