Posted on

nasal cbd

Nasal cbd

Calm your mind, reduce anxiety, and find relief… naturally.

All of our ingredients are derived from true natural sources and clearly listed on our labels.

CBD (Cannabidiol) is one of over 113 active compounds found in the hemp plant called cannabinoids. CBD interacts with body’s endocannabinoid system to naturally reduce anxiety, alleviate pain, and improve sleep without any psychoactive effects or “high” for the user.
You can learn more about CBD here.

Feel the amazing benefits of CBD at any time while keeping a clear mind.

Effective

Our products are continuously tested to ensure the highest quality purity and consistency.

100% All-Natural

Results: CBD was absorbed intranasally within 10 minutes with a bioavailability of 34-46%, except with 100% polyethylene glycol formulation in rats. Bioavailability did not improve with enhancers. The steady-state plasma concentration of CBD in guinea pigs after transdermal gel application was 6.3 +/- 2.1 ng/mL, which was attained at 15.5 +/- 11.7 hours. The achievement of a significant steady-state plasma concentration indicates that CBD is useful for chronic pain treatment through this route of administration. The steady-state concentration increased by 3.7-fold in the presence of enhancer. A good in vitro and in vivo correlation existed for transdermal studies.

Objective: Herein we have evaluated the IN and transdermal delivery of CBD with and without permeation enhancers.

Context: The nonpsychoactive cannabinoid, cannabidiol (CBD), has great potential for the treatment of chronic and ‘breakthrough’ pain that may occur in certain conditions like cancer. To fulfill this goal, suitable noninvasive drug delivery systems need to be developed for CBD. Chronic pain relief can be best achieved through the transdermal route, whereas ‘breakthrough’ pain can be best alleviated with intranasal (IN) delivery. Combining IN and transdermal delivery for CBD may serve to provide patient needs-driven treatment in the form of a nonaddictive nonopioid therapy.

Materials and methods: In vivo studies in rats and guinea pigs were carried out to assess nasal and transdermal permeation, respectively.

Conclusion: The results of this study indicated that CBD could be successfully delivered through the IN and transdermal routes.