What this means is that, theoretically, a person who consumes nano CBD as opposed to regular CBD may feel the effects more quickly. Dr. Mary Clifton, an NYC-based MD specializing in internal medicine, is also a CBD and cannabis expert and has worked with medical marijuana patients for more than 20 years in Michigan and New York State respectively.
Another area of concern lies in the safety of nanoparticles — when particles are made smaller, there may be unintended consequences. The increased use of nanotechnology in biomedicine, agriculture, and consumer products has led to the rise of nanotoxicology, the study of how engineered nano devices and structures may affect people. In reporting an explainer on weed wine for Weedmaps News, Josh Lizotte, founder and CEO of Rebel Coast, cautioned against the process of using nanoemulsions in cannabis-infused wine because “we don’t know the health effects of nanotechnology, and how such small particles [interact with] the body.”
The technology used in Nano CBD isn’t new.
Project CBD is a California-based nonprofit dedicated to promoting and publicizing research into the medical uses of CBD and other components of the cannabis plant. Their Chief Science Writer, Adrian Devit-Lee, is somewhat skeptical of nano CBD formulations. He agrees with Kurek that the nanoemulsion theoretically makes CBD easier for the body to absorb, but that it doesn’t mean it is “practically” easier to absorb.
this is the nano CBD cocktail I made with grapefruit and rosemary. I am with the company so I did some promo shots for them because I am a nice lady who would like to be rich one day pic.twitter.com/sGrnNzaFFY— mommy’s special computer time (@sistersleaze) December 31, 2019
Like any trend, nano CBD has its skeptics.
CBD, more formally known as cannabidiol, is everywhere. Given the incredible enthusiasm, you would never guess that CBD is not exactly legal, leaving CBD purveyors in a legal grey area. This lack of federal oversight has created a lot of wiggle room for companies seeking an edge or niche in an increasingly crowded and competitive space. One such niche is the very sci-fi sounding name nano (or water-soluble) CBD, touted as being more effective and bioavailable (the degree to which a nutrient is available for the body to use) than other formulations.
Nanotechnology is the application “of extremely small things” conducted at the nanoscale — about 1 to 100 nanometers. Nanotechnology is pretty widespread in medicine, beauty products, biomaterials, robotics, and now organic compounds such as CBD.
This carrier system allows multiple routes of administration and offers advanced therapeutic efficacy and safety for more difficult-to-deliver drugs.
Why Would Nano CBD Work Better Than Regular CBD?
However, there is still room for research, and CBD users should be careful when choosing their nano CBD brand. There is still some potential for risk when using nano CBD — but we can’t be sure until more research is conducted.
Nanotechnology isn’t something limited to the cannabis world; scientists have been experimenting with using nanoparticles for decades now, both in the hope of improving the effectiveness of other drugs and in possibly creating nanomachines that are capable of altering things on a subatomic level.
However, the bioavailability of a drug is what determines what percentage of the substance your body can actually utilize. With CBD, this is typically very low – sometimes as little as 6% when taken orally, as discovered by in a study conducted by Welty et al.
What is Nanotechnology?
With drugs, this happens on a much more microscopic level; when you first imbibe a substance, it finds its way to your liver, which is where it seems to be broken down into more elements that your body can actually use.
This occurs due to an enzyme called CYP3A4, which is what is responsible for turning the conventional chemical composition of drugs into something that can affect your body.
What is Bioavailability?
Of the few studies conducted about CBD nano, the overall consensus is one of positivity – generally speaking, it seems to work.