Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.
CBD can alter the effects of other drugs
Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.
Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included
Doubling up on side effects
The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.
Currently, not much is known about how CBD could interact with other medications, including ibuprofen. More research needs to be done, but current research has shown that CBD poses inhibitory action on some enzymes that galvanize drug metabolism.
First, let’s recap on what CBD oil is, then we’ll get into more of the details.
CBD has been used for thousands of years as an alternative remedy to help with pain, inflammation, depression, and anxiety. Individuals suffering from the following conditions may be more likely to use CBD oil with ibuprofen.
How should I take ibuprofen with CBD oil?
According to medical research, cannabinoids might offer significant ‘side benefits’ beyond treating chronic pain. So, we’re going to discuss whether you can take ibuprofen with CBD oil.
According to some medical journals, as CBD is often used by different kinds of patients, often with complex conditions and treatment plans, it’s important to know any potential safety issues when combining CBD oil with prescription drugs.
Why take ibuprofen?
Marijuana, another type of cannabis plant, also contains CBD, but it also contains what is commonly known as THC (tetrahydrocannabinol), which is psychoactive and not used in CBD oil.
As we can see, the main difference between CBD and ibuprofen is how they interact with pain response pathways.