Overall, the vaporized CBD is absorbed into your bloodstream within a minute or so, although it could be a few minutes before you experience the full effects. As well as being the fastest non-intravenous method, inhalation also offers the highest level of bioavailability.
It is relatively slow and can take up to 30 minutes to take effect. This taxing journey results in the loss of a lot of CBD. Huestis’ aforementioned 2009 study found that the bioavailability rate of orally consumed cannabinoids was between 4% and 20%.
A 2009 study by Huestis, published in Chemistry & Biodiversity, found that vaping cannabinoids has a bioavailability rate of 56%. Other data places it between 34% and 46%.
Things that impact our metabolism include age, genetics, digestive system health, and lifestyle.
A study published in Epilepsia in 2019 gave adults, prescribed with CBD for seizures, a single dose of 99% pure cannabidiol capsules on two occasions. The first saw the volunteers take the compound on an empty stomach. The second involved using CBD after consuming a high-fat breakfast containing 840-860 calories, approximately 600 of which came from fat.
The length of time it takes for CBD to work depends mostly on how you consume it. The cannabinoid only works when your body absorbs it. As a result, the CBD must make its way from the entry point into the bloodstream, where it can interact with cannabinoid receptors.
Also, if these two people tried the same experiment three months later, not only would the results differ between the two people again, they could also differ from their past results! Because of this, using CBD can sometimes require trial and error.
The method of consumption dictates the speed and level of absorption into your bloodstream. In general, the faster it gets to the bloodstream, the higher the bioavailability level.
CBD is a chemical compound found in and extracted from cannabis and hemp plants. Also known as CBD, this chemical belongs to a family of compounds called cannabinoids. Native to cannabis and hemp plant groups, cannabinoids can interact with our bodies when consumed to induce a range of potential effects.
What is CBD?
The effects of inhaling CBD are also likely to be strong. Smoking CBD can result in a bioavailability of roughly 31%, while vaping can reach a whopping 70% ( 11 , 12 ).
While they are placed on the skin like transdermal CBD products, topical CBD differs in that it is not designed to reach the bloodstream. Topical CBD products like lotions and shampoos are meant to induce a local effect on the area of the skin that they are applied to. Because of this, you may feel local effects from topical CBD relatively quickly.