As with anything, there are some potential side effects of CBD. 8 These include the following:
Potential Side Effects of CBD
Animal studies show that the use of CBD can decrease interest in alcohol, relieve symptoms of alcohol withdrawal, and, ultimately, lessen the risk of a relapse. 11
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Excessive alcohol misuse can damage cells. This can lead to an increased risk of inflammation and chronic diseases like liver disease, pancreatitis, certain kinds of cancer, and more. But CBD may help protect against cell damage. 3
But there could actually be benefits to taking CBD with alcohol, suggests Soyona Rafatja, a New York-based functional and integrative family medicine physician. One study in the journal Psychopharmacology found that people who had alcohol and a CBD capsule had lower blood alcohol levels than those who had alcohol alone, though they experienced the same impairments in cognition and motor coordination. Another study in Pharmacology Biochemistry and Behavior found that rodents experienced less alcohol-induced neurodegeneration if they received CBD through a topical gel while the alcohol was administered.
More research from Free Radical Biology & Medicine showed that rodents that ingested CBD 30 minutes before ingesting alcohol were less likely to experience alcohol-induced oxidative damage in the liver than those that didn’t have the CBD. While they’re just animal studies, experts think they’re quite telling. “Alcohol decreases autophagy [degradation of damaged cells] in the liver, causing fat to accumulate in the liver and therefore cause fatty liver, inflammation, and hepatitis,” Rafatjah explains. CBD does the opposite, spurring damaged cells to degenerate, which can counteract alcohol’s effects.
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Jordan Tishler, president of the medical cannabis practice InhaleMD and the Association of Cannabis Specialists, on the other hand, says there isn’t enough research to prove any interaction between alcohol and CBD. He’s more concerned about people mixing alcohol with THC—this, he says, increases THC levels in the blood eightfold.
So, the jury’s still out on the effects of combining alcohol and CBD, and experts can’t even seem to agree. If you’re going to take CBD and alcohol together, Giordano recommends at least keeping the doses low and trying both on their own first so you know how you react to them. “People who don’t drink or do CBD regularly, if they drink and do CBD together, good luck—that’s really going to be unpredictable,” he says. “If there’s any prediction at all, that prediction is, that person’s going to be pretty stoned.”
Even if you’re not slapping the two together in a drink, CBD and alcohol can interact if you take them within four to eight hours of each other, says James Giordano, professor of neurology and biochemistry at Georgetown University Medical Center. This means that if you have a drink with dinner then take CBD dab before bed, the CBD could have a stronger effect than it would without the alcohol.
For those who don’t know, cannabidiol [CBD] is a compound in weed with relaxant effects, but it’s not psychoactive in the way that THC is, so it won’t get you high. It’s sold as oil, in edibles, capsules, vape juice, and, apparently, alcohol.
Currently, there is not enough research to determine the effects of mixing wine and CBD. However, since both CBD and alcohol are known to reduce anxiety and induce relaxation, we can assume that when you use them together, these effects are amplified.
Unfortunately, there hasn’t been much rigorous research done on the interaction of CBD and alcohol. Currently, we still do not properly understand the interaction between CBD and alcohol. However, based on the above, we can make a few deductions.
Furthermore, some experts believe that because both substances have similar sedating effects, they may actually amplify each other. This means the overall experience could be more intense.
Since both CBD and alcohol lower your inhibitions, the effects could be especially intense and long-lasting when someone mixes the two substances. CBD makes you very chilled, mellow, and lighthearted. Alcohol may intensify those effects.
Is It Safe to Take CBD Oil and Wine Together?
Technically, alcohol is a depressant because it usually depresses the central nervous system (but it can also have stimulating effects). CBD is similar – it has energizing and alerting effects in small doses. In larger doses, it has more sedative-like effects.
Generally, the effects of alcohol will be more intense if you consume it within 4-8 hours of using CBD. Allowing wine and CBD to interact results in a greater loss of motor coordination, greater loss of inhibition, and greater loss of control. Essentially, when consuming both at the same time, the effects will be more intense than when you consume just one of the substances.
The reason for this could have something to do with the fact that CBD imitates the depressant effects of alcohol when you use the substances together. However, other chemical processes may be going on that require further research.
How CBD and Alcohol Interact with Each Other
Further research needs to be done on how exactly it reduces the alcohol level in the blood. One theory suggests that it reduces liver inflammation, which helps the body to metabolize the alcohol quicker.
If you do decide to use CBD and wine together, stick to a low amount of each to minimize the risk of experiencing adverse side effects.