Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors’ group. Here, the authors report that when administered 10 or 20 microg/1 microl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.
1 Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, División Ciencias de la Salud, Universidad Anáhuac Mayab, Mérida, Yucatán, México;
Dyssomnias: Problems initiating and maintaining sleep, and also excessive sleepiness
Marijuana, hashish, bhang amongst others are different names given to derived-products from the plant C. sativa . Among the molecules that constitute marijuana, Δ 9 -THC and CBD are the most significant compounds (Fig. 1 1 ) . Whereas Δ 9 -THCis the psychoactive molecule that binds to the CB1cannabinoid receptor and induces behavioral, neurochemical and molecular effects ; CBD does not promote psychotropic disturbances . Moreover, recent evidence suggests that CBD is a compound with potential medical uses.