At the end of the day, not all supplements are created equal, which is why it’s important to work alongside a healthcare provider when adding CBD to your wellness regimen and research reliable brands. And while emerging research and anecdotal evidence is promising, more large, randomized-controlled trials are needed to further understand the benefits of CBD and its dosing.
$45 per container
When you consume CBD gummies, capsules or softgels, dosage is typically expressed per unit. For example, there may be 50 milligrams of CBD in each individual gummy. These products don’t offer much dosage flexibility since you can’t split up capsules easily. For instance, if one softgel capsule didn’t provide your desired result, you would have to take another full capsule, doubling the total dose.
Without FDA approval, there is little guidance in the U.S. on how much CBD a person should consume for various conditions.
Can You Take Too Much CBD?
FDA-approved Epidiolex administers CBD orally as a liquid to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex. The dosage of Epidiolex is determined by taking the patient’s weight in kilograms (kg) into account.
Consumers can choose from a variety of CBD products, from oils to gummies to vapes to capsules. But figuring out the safe and effective CBD dose for an individual is a complex decision.
Several countries, including Canada and those in the U.K., have approved the use of Sativex, an oral spray with equal amounts of CBD and THC, to treat pain stemming from multiple sclerosis. Canada has also approved it for treatment of cancer pain.
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Like with any substance, you can take more CBD than your body can handle. Studies show doses up to 1,500 milligrams a day have been well-tolerated, but every person is different  Bergamaschi MM, Costa Queiroz RH, Zuardi AW, Crippa JAS. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Current Drug Safety. 2011;6(4):237-49. . Ingesting too much CBD can cause unpleasant side effects, such as dry mouth, nausea, diarrhea, upset stomach, drowsiness, lightheadedness and general disorientation. While rare, liver damage can also occur.
25mg÷2.5mg/drop = 10 drops
10 drops ×2.5mg = 0.5mL
Cytochrome P450 (CYP450) is an enzyme in your body that breaks down certain drugs. But CBD oil can block CYP450 from working the way it normally does. CBD oil can either make some drugs you take have a stronger effect than you need or make them less effective.
CBD oil may reduce the risk of heart disease by relieving high blood pressure in some people, per a 2017 study in JCI Insight.
There are no guidelines for the proper use of CBD oil. CBD oil is usually taken by placing one or more drops under the tongue and holding it there for 30 to 60 seconds without swallowing.
Dosage and Preparation
For the study, nine healthy men took either 600 mg of CBD or the same dose of a placebo. The men who took CBD had lower blood pressure before and after stressful things, like exercise or extreme cold.
A 2015 review of studies in the journal Neurotherapeutics suggests that CBD might help treat anxiety disorders.
Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California.
CBD's exact mechanism of action is unclear.
Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.