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cbd strains for epilepsy

Cbd strains for epilepsy

Hemp derived extract was given to 138 patients for epileptic seizures [14] . Sixty-eight percent of the study respondents reported decreased seizure severity or frequency from the effects of CBD. About 2/3 reported other effects of CBD such as better sleep and improved alertness. Adverse events were reported by 22% and included diarrhea, fatigue, and increased seizures.

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CBD can help treat various health problems, with the best CBD oil can be found here. While many drugs can treat epilepsy, none are known to prevent its development. A third of people with epilepsy remain resistant to their medications. This leaves them open to increased risk of sudden unexpected death from epilepsy-related seizures or impairments in psychosocial, behavioral, and cognitive functions. This resistance to traditional medications makes CBD products very appealing as an alternative treatment modality.

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Cbd strains for epilepsy

However, studies have shown that CBD, when taken with other anti-seizure medications, reduces the frequency and severity of seizures in people who have these disorders.  

Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles. She helped co-author the first integrative geriatrics textbook, "Integrative Geriatric Medicine."

What About Other Seizure Types?

Even with treatment, people with LGS or Dravet syndrome may continue to experience persistent seizures.

Epidiolex, a precription form, is approved for some seizures

Some other CBD products contained other compounds from the marijuana plant, including tetrahydrocannabinol (THC)—the part that gets you "high."

In most of the trials, CBD is used in adjunct with epilepsy medication, therefore it remains to be determined whether CBD is itself antiepileptic or a potentiator of traditional antiepileptic medications. Future trials may evaluate the efficacy of CBD in treating seizures due to specific etiologies (e.g., post-traumatic, post-stroke, idiopathic).

Introduction and background

In 1980, Cunha et al. conducted a double-blinded trial. They included 15 patients suffering from secondary generalized epilepsy with a temporal focus. Out of 15, eight patients were included in the treatment group and seven were included in the placebo group. Each patient in the treatment group received 200–300 mg of CBD daily for a period of eight to 18 weeks. Electroencephalography (EEG) and electrocardiography (ECG) were performed at 15–30 days interval. Four of the patients in the treatment group were seizure-free while three had partial improvement and the remaining one did not have any effect [11].

Table 1

Endocannabinoids (cannabinoids synthesized normally within the central nervous system (CNS)) have a role in decreasing the release of excitatory neurotransmitter in CNS, hence preventing from seizures [15]. They act on CB1 and CB2 receptors with former being expressed by central and peripheral neurons, while the latter are mainly expressed by immune cells but are also found in the brain cells [16]. An old thought of CB1 receptors being the only ones involved into neuronal activity regulation has been challenged by a recent experimental study on rats, which concluded that loss of both types of receptors will result into a spontaneous and more severe form of seizures than the loss of CB1 receptors alone [17]. This formulates that the development of potential drugs enhancing the activity of these receptors could be used as a therapeutic means for seizure disorders. Cannabis is extracted from the Cannabis Sativa plant, which has more THC than CBD. THC is psychoactive while CBD has little to no psycho-activity. Also, CBD has more antiepileptic properties, thus drawing attention to the preparations with more CBD to THC proportion [18]. Lesser adverse effects with CBD could be there because CBD has a weak activity at CB1 and CB2 receptors. CBD instead works by other mechanisms such as transient receptor potential (TRP) cation channels resulting in a decrease in the presynaptic release of glutamate [8,19].