Solutions of pure cannabinoids, nine samples of herbal and two of resin cannabis (one freshly prepared) were stored in varying conditions for up to 2 years. Exposure to light (not direct sunlight) was shown to be the greatest single factos in loss of cannabinoids especially in solutions, which should therefore be protected from light during analytical and phytochemical operations. Previous claims that solutions in ethanol were stable have not been substantiated. The effect of temperature, up to 20 degrees, was insignificant but air oxidation did lead to significant losses. These could be reduced if care was taken to minimize damage to the glands which act as “well filled, well closed containers”. Loss of tetrahydrocannabinol after exposure to light does not lead to an increase in cannabinol, but air oxidation in the dark does. It is concluded that carefully prepared herbal or resin cannabis or extracts are reasonably stable for 1 to 2 years if stored in the dark at room temperature.
CBD may increase the effect of endocannabinoids, like anandamide, in the body as well. Scientists believe CBD stops anandamide from being broken down too quickly, allowing this “bliss molecule” to build up in your system and amplify its effects.
THCO-A or THCo Acetate does not naturally occur in hemp or cannabis plants, nor is it a THC isomer. It is, however, a derivative of hemp products. THCO-A is synthesized from Delta-8, which is typically first created by synthesizing CBD.
Learn more about Delta-8 THC .
CBD & the Endocannabinoid System
CBD is a cannabinoid found in hemp and cannabis plants. In cannabis, CBD is second only to THC in prominence. But in hemp, CBD is the most potent compound. CBD is federally legal (when derived from hemp) and will not get you high regardless of origin.
Research on the ECS is still in fairly early stages, but experts have identified two primary receptors–CB1 and CB2. CB1 receptors are concentrated in the brain and nervous system and appear in your spinal cord and liver. CB2 receptors are present in the immune and gastrointestinal systems as well as the brain.
CBD & Delta-10 THC
CBD doesn’t bind with CB1 or CB2 receptors like other cannabinoids. THC unquestionably binds to CB1, and for a while, researchers thought that CBD was a CB1 antagonist. But CBD has shown little binding affinity for either receptor, leaving scientists to ponder its exact mechanism of action.
CBD has antidepressant effects in mice, and promising potential in humans, though studies are limited. A 2010 study suggested CBD counters depression by activating the serotonin receptor, 5-HT(1A). A 2019 study supports this, reporting CBD “promotes both a rapid and a sustained antidepressant effect in animal models” by inducing cellular and molecular changes in the hippocampus and prefrontal cortex in the brain, areas that are chemically affected by depression.