10. O’Sullivan SE. An update on PPAR activation by cannabinoids. Br J Pharmacol. 2016;173(12):1899–1910.
These days, it seems like you can purchase CBD just about anywhere, but if it’s an option, you may want to visit a medical marijuana dispensary. Buying CDB from a medical dispensary doesn’t guarantee the product’s quality but it’s a good place to start. Before you go:
What’s more, CBD has minimal side effects and a low-risk, zero-addiction profile. But before you pop a gummy or ingest an oil, you’ll want to read on.
13. Nuutinen T. Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus. Eur J Med Chem. 2018;157(5):198-228.
How long does it take for CBD oil to work for joint pain?
The 2018 US Farm Bill legalized the growing of hemp and sale of hemp-derived products, which made CBD legal at the federal level (mostly). As noted, hemp is a species of the marijuana plant with one very important distinction: the variety must have less than 0.3% THC. So, if the CBD you buy comes from a hemp plant with less than 0.3% CBD and is grown in accordance with the 2018 Farm Bill regulations, and you live in a state where CBD is legal, you are in full abidance of the law.
What can CBD (aka: cannabidiol) do for your chronic pain? This natural compound extracted from the Cannabis sativa plant will not get you high, since it does not produce the same psychotropic effects as its cannabinoid sibling, tetrahydrocannabinol (THC), but many people are finding that it can complement their pain care plan. In fact, research shows that of the 62% of people who use CBD for a medical condition, the majority are treating chronic pain, arthritis, and joint pain, as well as anxiety. 1
You can also vape a CBD isolate or broad spectrum oil, which should not induce a high.
WHAT ELSE TO EXPECT WHEN TAKING CBD
But it’s not that simple. CBD has been shown to decrease the psychotropic effects of THC, meaning that if a full spectrum extract has a greater ratio of THC to CBD, you won’t necessarily feel so high. Of course, everyone responds differently to marijuana and this will involve a lot of trial and error.
Remember that CBD use for pain and related symptoms is not an exact science, so you may need to try more than one brand and method before feeling relief. The good news is that, to date, CBD is not considered to be physically addictive, and there’s no history of anyone overdosing on it, so a little trial and error likely won’t hurt as long as you are sourcing safely.
CBD is emerging as a promising pharmaceutical agent to treat pain, inflammation, seizures, and anxiety without the psychoactive effects of THC. Our understanding of the role of CBD in pain management continues to evolve, and evidence from animal studies has shown that CBD exerts its pain-relieving effects through its various interactions and modulation of the endocannabinoid, inflammatory, and nociceptive (pain sensing) systems. The endocannabinoid system consists of cannabinoid receptors that interact with our own naturally occurring cannabinoids. This system is involved in regulating many functions in the body, including metabolism and appetite, mood and anxiety, and pain perception.
So far, pharmaceutical CBD is only approved by the FDA as adjunct therapy for the treatment of a special and rare form of epilepsy. Currently, CBD alone is not approved for treatment of pain in the United States. But a combination medication (that contains both THC and CBD in a 1:1 ratio) was approved by Health Canada for prescription for certain types of pain, specifically central neuropathic pain in multiple sclerosis, and the treatment of cancer pain unresponsive to optimized opioid therapy. There is currently no high-quality research study that supports the use of CBD alone for the treatment of pain.
What’s the research that CBD works in humans?
Cannabis (most commonly obtained from the Cannabis indica and Cannabis sativa plants) has three major components: cannabinoids, terpenoids, and flavonoids. While there are over a hundred different cannabinoids, the two major components are tetrahydrocannabional (THC) and cannabidiol (CBD). Historically more attention has been paid to the psychoactive (euphoric “getting high”) component of the cannabis plant, THC; there have been fewer scientific studies on the medical use of CBD, a non-psychoactive component of the plant.
Why is CBD presented to the public this way, when it is not without risks?
Given the rapid change in the legality of cannabis coupled with the increased appetite for something new, and driven by unprecedented profit margins, the advertising for cannabinoids in general and CBD in particular has gone wild. The FDA is very clear that it is illegal to market CBD by adding it to a food or labeling it as a dietary supplement. And it warns the public about its potential side effects, as it’s often advertised in a way that may lead people to mistakenly believe using CBD “can’t hurt.” CBD can cause liver injury, and can affect the male reproductive system (as demonstrated in laboratory animal studies).
"Some of the anti-inflammatory effects are the result of the interaction of cannabis components with CB2 receptors in the brain," explains Dr. Lam. "If activated, the receptors release fewer pro-inflammatory substances called cytokines—which means less inflammation."
A study of 29 patients with peripheral neuropathy (weakness, numbness, and pain from nerve damage) in their lower extremities found that topical CBD provided a "statistically significant reduction" in pain over a placebo. In contrast, a 2020 review of research on CBD's connection to pain, also published in Frontiers in Pharmacology, found that in "studies of generalized chronic pain, CBD treatment did not significantly reduce measures of pain." The authors did note, however, that "there was consistent improvement in patient-reported quality of life and quality of sleep." If this is an avenue you're interested in exploring, talk to your primary care physician before making any changes to your pain management regimen.
This full-spectrum CBD oil from Green Roads is vegan and gluten-free, plus it comes in three different strengths—mild, moderate, and mighty. The formula has no artificial flavors or colors, and the hemp used is farmed in the U.S. The dropper features an easy-to-use measuring system and each box has a QR code that links directly to the independent lab results for that specific product.
Strongest Tincture: cbdMD Broad-Spectrum CBD Oil
Choosing a CBD oil for pain relief involves more than just picking a flavor or potency. Here are a few things to consider when shopping for a CBD product.
Potency: 80 milligrams of CBD per 1 milliliter serving
Top CBD oils for pain in 2021
The amount of CBD you should take depends on a number of different factors, including your height, weight, and whether or not you've used CBD oil before. Consult a doctor about proper doses if you're planning to use a product for pain management.
CBD oil can be taken as drops under the tongue or as a capsule, and it can also be applied directly to the skin in topical form. Sublingual drops typically take 30 minutes to start working while it may take up to two hours to feel the effects of capsules, gummies, and topicals.