Food industry news, voices and jobs. Optimized for your mobile phone. CBD has recently be praised as a "miracle drug." However, even though it is holistic and safe, CBD does have some side effects associated with its use. ‘Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us.’
Study: CBD does not cause liver damage
Despite CBD’s popularity and increasing ubiquitousness, questions still linger regarding the safety and long-term impact of using the hemp and cannabis-derived substance.
Since hemp is now legal and CBD is becoming more mainstream, the FDA has come under pressure to clarify its stance on the ingredient so manufacturers eager to capitalize on the growing demand can develop products that can be sold.
A summer 2019 study involving mice suggested that there may be a link between CBD and liver damage. Critics pushed for a human study, like Validcare’s, saying there are differences between how CBD functions in mice versus humans, and most people would not ingest the level of CBD provided to rodents in the study.
The results of the study are likely good news for players in the CBD industry who may have been fearing heavy restrictions, should the results have raised red flags.
There are still plenty of other health-related questions about CBD to tackle. These stem from the relative newness of the ingredient and the lack of long-term research on side effects or how it may interact with medications. As a result, the FDA has cracked down on CBD-containing products making health claims or statements about what the ingredient can accomplish.
Consumers are showing increasing eagerness to add CBD to their daily regimens, with 40% saying in March 2019 that they would try CBD, according to a study by High Yield Insights. The ingredient got a boost during the COVID-19 pandemic, as consumers sought ways to relax, ease tension and improve sleep quality.
The lack of FDA regulations around CBD has not stopped companies from planning and creating products. These include completely new offerings and reimagined versions of existing ones. Unilever-owned ice cream maker Ben & Jerry’s was the first to hint at the possibility of adding CBD to some products after hemp cultivation was legalized in the 2018 Farm Bill. Soon after, Mondelez’s CEO announced that the company is exploring CBD snacks . Smoothie maker Bolthouse Farms has also expressed interest in developing a CBD-infused line of its drinks, but progress has been slow due to regulatory ambiguities , said the company’s vice president of marketing.
Drink makers seem to be leading the charge when it comes to getting CBD products on store shelves. Ocean Spray’s Lighthouse incubator launched a line of sparkling CBD water called CarryOn, while Constellation Brands’ Canopy Growth launched its own bubbly CBD beverage, Quatreau . Truss CBD USA, a partnership between Molson Coors Beverage Company and Canadian cannabis grower Hexo, has also debuted a sparkling CBD drink called Veryvell in the U.S.
With the number of states legalizing cannabis increasing and a new administration that appears more favorable toward the substance, momentum around CBD is gaining speed. Manufacturers have little reason to stop making CBD products to satiate growing consumer demand, but the FDA has a critical role to play in determining how many of them will come to market.
What Are Some Common Side Effects of CBD Oil?
CBD, one of the main components of the cannabis plant, is now being looked at as a highly effective remedy for all kinds of conditions.
Although not enough research has been conducted to prove it can cure any specific ailments, research indicates it can be effective in treating a wide variety of health issues.
When you read about all of its benefits, it almost seems like some kind of “miracle drug.”
Unfortunately, there is no such thing as a miracle drug.
Even though it is holistic and safe, CBD does have some side effects associated with its use.
How Has This Been Proven?
Some advocates will argue that CBD has no negative side effects, and there are reasons for that attitude.
Indeed, the side effects of CBD are very mild when compared to most pharmaceutical products, but they are still there.
As far as we can tell, the best evidence for these side effects comes from a series of medical trials on Epidiolex.
Epidiolex is a commercial drug and its main ingredient is CBD.
As such, it had to be rigorously tested and vetted by the FDA and other organizations.
They found that CBD (or at least, this form of CBD) had a few negative consequences associated with its use.
These include several minor problems like sleepiness and decreased appetite.
The only serious side effect would seem to be an increase in liver enzymes.
As you probably know, CBD won’t get you “high” in any way.
A different part of the cannabis plant (THC) is responsible for those effects, so pure CBD is non-intoxicating.
However, most users do report that CBD makes them feel calm and relaxed.
This may be an explanation for the reported side effects of sleepiness and lack of energy.
To be fair, we should mention that this aspect is not necessarily a problem.
For those who are dealing with insomnia issues, this side effect could actually be a benefit.
Still, it might be a good idea to avoid driving a car for about an hour after taking CBD.
There were some people in the medical trials that experienced rash, skin irritation, and other signs of an allergic reaction.
This isn’t really too surprising since all plants have the potential to cause an allergic reaction.
This is ironic because CBD tends to have antihistamine properties, meaning that it can be used to fight allergies.
Of course, there are numerous levels of reaction, and some of them are pretty mild.
A mild allergy might be nothing more than an itchy sensation in your nose, while a severe reaction could involve violent puking and breathing problems.
Allergies to CBD products are rare, but it pays to take some precautions.
When using it for the first time, put a small sample on your skin for a test.
Wait 24 hours to see if a rash develops before taking the CBD internally.
Lack Of Appetite
This is something that we didn’t expect to see, mostly because cannabis has a reputation for making people hungry (i.e., “the munchies”).
It would seem that CBD alone has the opposite effect.
After a large dose of CBD, people are actually a lot less likely to eat.
It is believed that this is caused by the action of CBD on the receptors of the brain.
By indirectly blocking the receptors that govern hunger, CBD makes the brain less focused on those culinary desires .
This can be a real problem for those with malnutrition issues or those who are already taking appetite-reducing medications.
However, some have also touted this side effect as a benefit for those who are overweight.
Some of the literature on this subject claims that CBD can cause liver cancer when used in large amounts.
This claim is still a little dubious, but there is one solid fact to be found.
CBD does seem to increase the levels of liver enzymes found in the blood.
In case you don’t know, enzymes are special proteins that the body uses to “kick-start” certain reactions.
Whenever the liver is damaged, these enzymes will begin leaking into the bloodstream.
An elevated level of liver enzymes in the blood doesn’t usually signal a serious condition, but it does indicate some level of trauma to the liver itself.
That is why some researchers claim that CBD can cause liver cancer.
However, this could have been the result of the other ingredients that were present in Epidiolex, so alternative tests using pure CBD are needed.
Based on current research, t he side effects of CBD are extremely mild.
Always stick with the recommended dosages and consult with your doctor before beginning any healthcare regimen.
64 million Americans have tried CBD and now the FDA says it could cause liver damage
‘Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us’
The FDA issued a warning to consumers about potential health effects from CBD, including liver damage.
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Brandon Warne, a Minnesota Twins beat reporter for the sports news outlet Zone Coverage, started taking cannabidiol (CBD) in August after growing increasingly frustrated with his depression and anxiety medications over the past four years.
“I was just at a point where nothing was working for me,” Warne, 33, of Minnesota’s Twin Cities area, told MarketWatch. “I was just trying to branch out because I was just so upset [and] distraught with my lack of progress towards mental health.”
Under the guidance of his psychiatrist and therapist, Warne started taking CBD and pared down his medication list. He tapered off the antidepressants bupropion GSK, -2.39% and Effexor PFE, -2.64% , but continued to take his anti-anxiety medication, buspirone TEVA, -3.96% , after experiencing “wicked side effects” from trying to go off of it. He now takes CBD in the form of a 0.5-ml dose of Clean Remedies full-spectrum hemp extract oil every morning, and plans to eventually try to taper the buspirone as well.
Warne, who received his diagnoses after his grandfather’s death, wonders whether he was misdiagnosed. But the results he has seen since taking CBD, he said, have been “moderately positive.” “I’ve been feeling great since I got off my meds,” he said.
“ ‘We remain concerned that some people wrongly think that the myriad of CBD products on the market, many of which are illegal, have been evaluated by the FDA and determined to be safe, or that trying CBD ‘can’t hurt.’ ”
— — Amy Abernethy, FDA principal deputy commissioner
Warne isn’t entirely sure whether it’s the CBD oil or being off his meds that’s causing the improvement, but he is willing to continue trying CBD when he’s done with his current bottle. He said he still has “research” to do on the matter — and a new FDA warning backs him up.
The Food and Drug Administration said late Monday that what you don’t know about CBD might hurt you and warned that it could cause serious health problems, including liver damage.
The warning comes as millions of consumers have jumped on board with the non-psychoactive cannabis compound for reasons relating to health, wellness and recreation, and CBD has popped up on restaurant menus, in post-workout salves and in bath bombs.
The FDA sent letters warning 15 companies for illegally selling CBD-containing products. The federal agency also updated its position to clarify that the substance increasingly infused in pills, lotions, food products and wellness beverages “has the potential to harm you, and harm can happen even before you become aware of it.”
“We remain concerned that some people wrongly think that the myriad of CBD products on the market, many of which are illegal, have been evaluated by the FDA and determined to be safe, or that trying CBD ‘can’t hurt,’” Amy Abernethy, the FDA’s principal deputy commissioner, said in a statement.
The only CBD product approved by the FDA is the prescription drug Epidiolex, which treats pediatric epilepsy. It’s illegal to market CBD as a dietary supplement.
The compound can cause liver injury, interact with other drugs, and increase the risk of drowsiness and sedation when used with alcohol, the FDA said. Studies using lab animals have also shown negative impacts on the male reproductive system, though the takeaway for human patients remains unclear, the FDA said.
The agency also provided a list of potential side effects related to CBD, including sleepiness, diarrhea and/or a decrease in appetite, and mood changes such as agitation and irritability.
Many questions, not many answers
Scientists still don’t know what happens if a person consumes CBD daily for sustained time periods; the compound’s effect on children who take CBD, growing fetuses or breastfed newborns; its interactions with herbs and botanicals; and whether it leads to the same male reproductive problems in men as observed in animals, the FDA said.
What’s more, the FDA is concerned about “a lack of appropriate processing controls and practices”: Many products tested by the FDA have contained different CBD levels than what manufacturers claimed, and there have been reports of products containing unsafe levels of pesticides, heavy metals and THC, the agency said.
“I still don’t think it’s so harmful that I shouldn’t use what I have,” Warne said in response to the new FDA warning. “But it certainly makes me question how settled the science is … and maybe it’s not as ironclad as I thought it was before.”
64 million Americans have tried CBD
Research published this year by the consumer-data firm MRI-Simmons estimated that 3.7 million U.S. adults were CBD consumers, with a median age of 45. Even more appear to have dabbled in the substance: Some 64 million Americans — 26% of the country — report having tried CBD in the last two years, according to a nationally representative Consumer Reports survey of more than 4,000 people conducted in January. One in seven of those respondents reported daily use.
And many CBD users use the compound for its health potential, though their outcomes tend to be mixed.
More than a third of respondents to the Consumer Reports survey said they used CBD to reduce stress or anxiety or promote relaxation; 63% of those people said the compound was “extremely or very effective” at doing so, while 16% said it was not at all or only slightly effective. Nearly one in four respondents said they used CBD to help with joint pain, with 38% calling it “extremely or very effective” and 27% saying it was slightly or not at all effective.
The Mayo Clinic says that “although some research appears to indicate that CBD might hold benefit for treating anxiety-related disorders, more study is needed.” And physician Peter Grinspoon, writing on the Harvard Health Blog, noted that an animal study had shown that applying CBD to the skin could help lower arthritis-related pain and inflammation. “More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control,” he added.
Warne is not alone in using CBD to replace or supplement a medication: 30% of respondents to the Consumer Reports survey said they had taken CBD in addition to a prescription or over-the-counter medication, while 22% said they replaced the medication with CBD entirely. A third of those who replaced a medication with CBD said that the drug was a prescription anti-anxiety drug.
Still, Warne called the FDA’s words of caution “prudent” and agreed that more research should be conducted on CBD’s benefits and risks.
“Hopefully it stands up — because otherwise, we’re kind of all owed an explanation for why this was pushed on us for the past year or however long this has been popular,” he said. “Hopefully we get an explanation one way or the other.”