This study documents the anti-cancer effects of CBD alone and in combination with chemotherapy drugs. It also provides hints as to the mechanisms and pathways that CBD influences in canine cancer cells. Additional study is needed to better understand these mechanisms and define safe and effective dosages for dogs. Whether CBD is used as a primary treatment or to manage the side effects of chemotherapy, additional knowledge will allow for safer and more effective use. CHF and its donors remain committed to exploring new and better treatments for canine cancer, like CBD. Learn more about our cancer research at akcchf.org/oncologyRPA.
Cannabidiol (CBD) is one of many chemicals identified in the Cannabis sativa plant, commonly known as hemp. It has been used for palliative care in oncology, but recent studies in humans and rodent models show that it may have direct anti-cancer effects. Since there is little data on the effects of CBD in canine cancer, investigators at Cornell University are studying what happens to canine cancer cells when they are exposed to CBD alone or in combination with common chemotherapy drugs (AKC Canine Health Foundation (CHF) Grant 02643-A: Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity). Results were recently published in Veterinary and Comparative Oncology 1 and offer hope for canine cancer patients.
1. Henry, J. G., Shoemaker, G., Prieto, J. M., Hannon, M. B., & Wakshlag, J. J. (2020). The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis. Veterinary and Comparative Oncology, e12669, e12669. https://doi.org/10.1111/vco.12669
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Cell cultures from different canine cancers (osteosarcoma, mammary carcinoma, and lymphoma) were exposed to various concentrations of CBD alone and in combination with the common chemotherapy drugs doxorubicin and vincristine. CBD oil caused a significant decrease in cancer cell reproduction in all cell lines studied. Use of CBD-rich whole help extract was able to reduce cancer cell reproduction at lower concentrations than CBD oil alone. This is likely due to the ‘entourage effect’ where the mixture of numerous chemicals seems to work in concert to produce a greater effect. The phenomenon needs more study though, since different cancers have different receptors for these chemicals and not all cultured hemp plants contain the same amounts of these chemicals. CBD in combination with the chemotherapy drug vincristine also decreased cancer cell reproduction in a synergistic way – or with greater effect than either chemical alone. When CBD was combined with doxorubicin, the results varied depending on the concentration of each chemical used.
A study found that mice had a increased survival rate when taking CBD with anti-tumor medication. CBD oil is natural with few side effects that disrupt the anti-tumor treatment, making it a safe supplement for your dog.
Keep in mind that some of these symptoms are also common in dogs with anxiety problems , or simply characteristics of dogs who are getting older.
Like humans, our canine companions are susceptible to cancer, with 1 in 3 dogs developing some form of cancer in their life. 1 in 4 dogs will develop neoplasia, the abnormal growth of cells or tissues within the body. The main cause of deathfor dogs over 2 years old is cancer, and half of the number of dogs over the age of 10 are likely to develop it. Clearly, cancer is common enough that dog owners should familiarize themselves with the main types of dog cancers and how they are treated.
May Improve Sleep
By interacting with the dog’s endocannabinoid system, the CBD can help to effectively manage many different types of pain . For this reason, CBD is growing in popularity as a tool to improve the quality of life in dogs or as a dual treatment method with more traditional therapies.
Despite growing popularity, CBD still suffers fromsomething of an identity crisis, with some people still people failingto make the distinction between CBD and marijuana. While it’s true thatCBD and marijuana do come from the same plant, the chemical makeup ofthe Cannabis Sativa plant means that the plants harvested for CBD andmarijuana have different properties. To produce CBD oil, a higher CBD concentration of CBD and minimal levels of THC are required, leading producers to favor the hemp plant.
Diagnosing and Treating Your Dog
Like for humans, CBD and hemp oils have long been used in traditional communities to treat pain in dogs resulting from a range of illnesses including cancer and muscular injuries.
As you’ll see, CBD is a great auxiliary treatment for dogs undergoing painful treatment regiments, or a way to improve the quality of life for pets whose owners decide extensive and invasive treatment isn’t the right option for an aging dog.
What is CBD Oil and How Does It Help With Dogs’ Cancer?
Our products are manufactured in the U.S., but we trust our friends in Belgium with the hemp carrier oil that goes into Innovet CBD. Everything about our pet CBD for dogs is legal in the U.S. so that you can place your orders online without any hesitation! Did we mention our CBD is entirely natural?
Are There Different Kinds of CBD for Dogs I Can Get Prescribed?
It’s necessary to remember that this is not a cancer treatment. For emphasis, CBD cannot treat cancer in dogs. It will not stop cancerous cells from growing, nor will it halt the progression of metastatic cancer cells in dogs. Instead of being a treatment, CBD is a way to relieve the not-so-great side effects of going through cancer treatment.