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With 1500 mg of CBD per bottle, this tincture offers impressive potency for a reasonable price. Featuring organic MCT coconut oil as a carrier, this lab-tested broad-spectrum CBD tincture includes high CBD concentrations without packing any artificial ingredients that you don't want in your body.
Type of CBD Used
Colorado Botanicals products are broad-spectrum CBD. While they are THC-Free, they do contain minor cannabinoids and terpenes.
It’s Worth Paying A Little More for CBD
CBD has a wide spectrum of biological activity, including antioxidant and anti-inflammatory activity, which is why its activity in the prevention and treatment of diseases whose development is associated with redox imbalance and inflammation has been tested [4,19,20]. Based on the current research results, the possibility of using CBD for the treatment of diabetes, diabetes-related cardiomyopathy, cardiovascular diseases (including stroke, arrhythmia, atherosclerosis, and hypertension), cancer, arthritis, anxiety, psychosis, epilepsy, neurodegenerative disease (i.e., Alzheimer’s) and skin disease is being considered [20,21,22]. Analysis of CBD antioxidant activity showed that it can regulate the state of redox directly by affecting the components of the redox system and indirectly by interacting with other molecular targets associated with redox system components.
3. Biological Activity of CBD
CBD is also an agonist of adenosine A2A receptors , which are G-protein coupled receptors. They are expressed in various cell types, participate in numerous physiological and pathological processes and also regulate inflammatory processes . Adenosine and its agonists exhibit anti-inflammatory activity in vivo . Therefore, adenosine release is one of the mechanisms of immunosuppression during inflammation , and adenosine receptor agonists reduce TNF-α levels [108,109]. It has been shown that CBD by activating A2A adenosine receptors can reduce the level of vascular cell adhesion molecule (VCAM-1) in endothelial cells in SJL/J mice, which may provide a new mechanism to control neuroinflammatory diseases such as multiple sclerosis (MS) .
4.1. CB1/CB2 Receptors
Chemical structure of cannabidiol (CBD) .