Similarly to antidepressants, CBD oil can take a while to start working. However, one should not exceed the maximum dose recommended by their doctor.
This CYP450 pathway is comprised of several different enzymes that act on various substances. Therefore, when one takes two drugs that are metabolized by the same enzymes together, an interaction can occur.
Since many antidepressants carry a long list of potential side effects, more and more people are turning to natural alternatives. One such option that has gained much attention in recent years is CBD.
The CYP450 pathway also metabolizes CBD in the liver. The specific enzymes responsible for breaking down CBD are:
Using CBD for Depression and Anxiety
SSRI antidepressants work by boosting the amount of serotonin in the brain. Serotonin is a neurotransmitter associated with feelings of happiness and well-being. Furthermore, low serotonin levels are associated with conditions like depression.
One of the best-known endocannabinoids is called anandamide. It gets its name from the Sanskrit word for ‘bliss,’ which should give you some idea of its function. Among other things, anandamide regulates the serotonin system in the brain. It is released under stressful conditions and helps to restore a sense of calm.
Nowadays, more people are turning to CBD to relieve the symptoms of anxiety and depression. However, scientists are still trying to ascertain exactly how the cannabinoid works for these conditions.
How Does the Body Process CBD?
Lexapro is the brand name for a drug called escitalopram. It is a selective serotonin reuptake inhibitor (SSRI). SSRIs are a class of antidepressant. They’re used to treat major depressive disorder and generalized anxiety disorder.
If using CBD oil is inconvenient or doesn’t taste great, one could also try CBD capsules, edibles, or vaping.
While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.
Doubling up on side effects
Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
CBD can alter the effects of other drugs
The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.