Devit-Lee also notes that every state has different testing requirements, and each lab has a different formulation for detecting drugs. In other words, just because it says something on the label doesn’t make it so. “If you have a good product that has some terpenes that help with absorption and with medicinal effects — if it’s a good quality product in general you don’t need to do this nanoformulation. But if you have bad quality hemp products, maybe [nano] can help them stand out,” he added.
Kurek begins by noting that nano-sized delivery technologies are not unique to CBD and are widely used by pharmaceutical companies to ensure bioavailability. “Nano CBD is a CBD molecule coated with very small particles, such as liposomes or lipid nanoparticles (LNPs), that stabilize the CBD and can move in our blood faster than ‘naked’ CBD, to effectively reach the target,” he explained.
Though most CBD products come in packages designed to keep out light, the simple act of opening and closing the container will reduce its efficacy. McDonald says that the nanoemulsion process itself insulates their products from degradation — though it should be noted the research backing this is scant — and all their packaging, with the exception of water, is opaque to keep out light.
Dr. Itzhak Kurek, Ph.D., is the co-founder and CEO of Cannformatics, a Northern California biotech company using saliva metabolomics technology to personalize medical cannabis treatment. Weedmaps spoke with Kurek to learn more about nanoparticles and the science behind them.
Like any trend, nano CBD has its skeptics.
What this means is that, theoretically, a person who consumes nano CBD as opposed to regular CBD may feel the effects more quickly. Dr. Mary Clifton, an NYC-based MD specializing in internal medicine, is also a CBD and cannabis expert and has worked with medical marijuana patients for more than 20 years in Michigan and New York State respectively.
The bottom line is that there just isn’t much research for a persuasive argument either way. The only thing consumers can really do is to shop thoughtfully for CBD — nano or not — and buy from U.S. companies that can easily show you their third-party lab results and certificate of analysis.
But clear CBD water bottles that could sit on store shelves for weeks or even months under the blazing lights of a grocery store aisle might be CBD-free by the time they’re purchased and consumed.
The technology used in Nano CBD isn’t new.
CBD, more formally known as cannabidiol, is everywhere. Given the incredible enthusiasm, you would never guess that CBD is not exactly legal, leaving CBD purveyors in a legal grey area. This lack of federal oversight has created a lot of wiggle room for companies seeking an edge or niche in an increasingly crowded and competitive space. One such niche is the very sci-fi sounding name nano (or water-soluble) CBD, touted as being more effective and bioavailable (the degree to which a nutrient is available for the body to use) than other formulations.
But nano CBD exists in a world with such a confounding range of CBD products available that can be found in the oddest of places — like the neighborhood bodega, alongside the condoms and Five Hour Energy packets — it begs the question: Is nano CBD a genuine innovation, or a gimmick to help companies differentiate themselves from the pack?
Over the past several years, FDA has issued several warning letters to firms that market unapproved new drugs that allegedly contain cannabidiol (CBD). As part of these actions, FDA has tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to contain. It is important to note that these products are not approved by FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease. Consumers should beware purchasing and using any such products.