And in lab studies, CBD has been shown to inhibit certain enzymes responsible for the metabolism of drugs, such as CYP2D6 and CYP3A4. This can affect how drugs work and affect our bodies, either by reducing their efficiency or making them more dangerous. This includes chemotherapy and other medications.
Third, the plant itself may have higher levels of THC than expected. This could be due to its environment, prolonged flowering periods or cross-contamination and pollination between male and female plants, resulting in offspring with higher THC content. This especially affects hemp plants, which should have less than 0.3% THC levels.
The main difference is that hemp has far less THC than a typical marijuana plant. And unlike THC, CBD is not a psychoactive agent, so there’s less possibility that it will cause the same mental confusion, drowsiness or hallucinations that often come with THC.
CBD oil can adversely affect liver function. In fact, this is on the warning label for Epidiolex.
Is CBD oil even legal?
There have been reports that cannabinoids like THC and CBD may be helpful for nausea and vomiting and anorexia, as well as neuropathy, anxiety, depression and insomnia. Synthetic cannabinoids like dronabinol have been approved for use with chemotherapy-induced nausea and vomiting, but have not been shown to be superior to conventional anti-nausea medications.
Is there any truth to the claims that CBD oil can cure cancer?
Marijuana and hemp are both varieties of the cannabis sativa plant. Both contain cannabidiol (CBD) and tetrahydrocannabinol (THC) — the two most-common, known active ingredients.
Western blotting was carried out as previously described 30 . Immunoreactive proteins were visualized by the chemiluminescence protocol (DoGEN ECL).
Sharafi, G., He, H. & Nikfarjam, M. Potential use of cannabinoids for the treatment of pancreatic cancer. J. Pancreat. Cancer 5, 1–7 (2019).
Cannabidiol (CBD) is one of the Cannabis sativa extracts that does not contain psychoactive components and is considered more useful than tetrahydrocannabinol, a psychotropic active cannabinoid, in clinical applications 1,2 . CBD is known to have antitumor activity against Noxa activation, inhibition of mTOR/cyclin D1, and G-protein-coupled receptors/mitogen-activated protein kinase pathway in various cancers such as pancreatic 3,4 , glioblastoma 1 , colorectal 5 , and breast cancer 6 . It also has beneficial effects on brain function, metabolism, and pain reduction 7,8,9 . However, there have been few reports on the anticancer mechanism by CBD in gastric cancer.
TdT-mediated dUTP nick-end labeling assay
Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangwon, 210-702, Korea