There is no cure for Parkinson’s disease. Because symptoms don’t exhibit themselves until the later stages of the disease, early diagnosis is difficult—but scientists continue to search for ways to identify the early onset of Parkinson’s. While no treatment options currently available can slow or halt the progress of Parkinson’s disease, there are treatments available to improve its symptoms.
They found that a single dose of 10.0 mg/kg of CBD recovered memory while repeated CBD administration of either CBD dose improved recognition memory. They concluded that the evidence suggests that CBD shows potential for the treatment of cognitive decline associated with neurodegenerative disorders.
CBD for Parkinson’s Disease
The result of this is a gradual loss of motor control, with symptoms starting gradually, usually with a noticeable tremor in just one hand. However, people with Parkinson’s disease also often exhibit emotional and behavioral changes, including sleeping problems and depression. Taken together, this makes Parkinson’s a debilitating disease that affects the patient, but also those around them.
A sensation of internal tremors, which are not necessarily visible to others.
CBD as a complementary treatment for Parkinson’s
Although they didn’t find a statistically significant different between the group for motor and general symptom outcomes or neuroprotective effects, they did find that the patients treated with 300 mg/day of CBD had a significant improvement in their quality of life. However, the researchers also noted that studies with larger samples and specific objectives are required before definitive conclusions can be drawn.
Parkinson’s disease (PD) is a common and complex neurological disorder that encompasses a range of clinical, epidemiological, and genetic subtypes. Loss of dopaminergic neurons in the substantia nigra leading to striatal dopamine depletion is the core mechanism underlying the cardinal motor features of PD. Although depletion of dopamine is the most notable neurotransmitter change in PD, other neurochemical changes occur and contribute to PD symptomatology. Many regions of the nervous system outside the basal ganglia are also involved in PD. The underlying molecular pathogenesis involves multiple pathways and mechanisms, such as α-synuclein proteostasis, mitochondrial function, oxidative stress, calcium homeostasis, axonal transport, and neuroinflammation.
Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil, Irmandade da Santa Casa de Misericórdia de Porto Alegre (ISCMPA), Porto Alegre, RS, Brazil
There has been interest in cannabidiol (CBD) as a treatment option for PD because of the identification of multiple potential targets of action in the CNS. CBD is one of the many cannabinoids identified in Cannabis sativa, being the second most abundant constituent after Δ9-tetrahydrocannabinol (THC). Unlike THC, CBD is non-psychoactive, and has been ascribed many potential medical benefits.