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cbd chemioterapia

Nabilone is a drug developed from cannabis. It is licensed for treating severe sickness from chemotherapy that is not controlled by other anti sickness drugs. It is a capsule that you swallow whole.

Cannabis that contains high levels of THC can cause panic attacks, hallucinations and paranoia.

How you have it

Clinical trials need to be done in large numbers where some patients have the drug and some don’t. Then you can compare how well the treatment works.

Scientists also discovered that cannabinoids can:

Research into cannabinoids and cancer

There are also many cannabis based products available online without a prescription. The quality of these products can vary. It is impossible to know what substances they might contain. They could potentially be harmful to your health and may be illegal.

Experimental approach: The ability of acute CBD pretreatment to prevent PAC-induced mechanical sensitivity was assessed, as was the effect of CBD on place conditioning and on an operant-conditioned learning and memory task. The potential interaction of CBD and PAC on breast cancer cell viability was determined using the MTT assay.

Key results: PAC-induced mechanical sensitivity was prevented by administration of CBD (2.5 – 10 mg·kg⁻¹) in female C57Bl/6 mice. This effect was reversed by co-administration of the 5-HT(1A) antagonist WAY 100635, but not the CB₁ antagonist SR141716 or the CB₂ antagonist SR144528. CBD produced no conditioned rewarding effects and did not affect conditioned learning and memory. Also, CBD + PAC combinations produce additive to synergistic inhibition of breast cancer cell viability.

Conclusions and implications: Our data suggest that CBD is protective against PAC-induced neurotoxicity mediated in part by the 5-HT(1A) receptor system. Furthermore, CBD treatment was devoid of conditioned rewarding effects or cognitive impairment and did not attenuate PAC-induced inhibition of breast cancer cell viability. Hence, adjunct treatment with CBD during PAC chemotherapy may be safe and effective in the prevention or attenuation of CIPN.

Background and purpose: Paclitaxel (PAC) is associated with chemotherapy-induced neuropathic pain (CIPN) that can lead to the cessation of treatment in cancer patients even in the absence of alternate therapies. We previously reported that chronic administration of the non-psychoactive cannabinoid cannabidiol (CBD) prevents PAC-induced mechanical and thermal sensitivity in mice. Hence, we sought to determine receptor mechanisms by which CBD inhibits CIPN and whether CBD negatively effects nervous system function or chemotherapy efficacy.

Keywords: 5-HT1A; CIPN; breast cancer; cannabidiol; cannabinoid; chemotherapy-induced neuropathic pain; mechanical sensitivity; paclitaxel.

Cbd chemioterapia

7. García de Palau M, Bouso JC. Desarrollo de programas de cannabis medicinal. Riesgos asociados a los tratamientos con cannabis. En: Efectos terapéuticos de los cannabinoides. Ed: Instituto Universitario de Investigación en Neuroquímica de la Universidad Complutense de Madrid. 2017. p. 219-34.

To date, only one clinical trial has been conducted specifically to analyse the combined effect of cannabinoids and an antitumour drug. This trial, conducted in hospitals in the UK and Germany amongst patients with recurring glioblastoma, analysed the safety and effectiveness of combining temozolomide and Sativex, a cannabinoid drug containing approximately the same amount of THC and CBD:

6. Scott KA, Dalgleish AG, Liu WM. The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model. Mol Cancer Ther. 2014;13(12):2955-67.

5. Miyato H, Kitayama J, Yamashita H, Souma D, Asakage M, Yamada J, et al. Pharmacological synergism between cannabinoids and paclitaxel in gastric cancer cell lines. J Surg Res. 2009;155(1):40-7.

Precautions

4. Torres S, Lorente M, Rodriguez-Fornes F, Hernandez-Tiedra S, Salazar M, Garcia-Taboada E, et al. A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther. 2011;10(1):90-103.

Increasing numbers of people are turning to cannabis in search of a complementary or alternative therapeutic option for treating their ailments. One of the questions they most often ask is whether they can use cannabis while undergoing conventional treatments.

As well as chemotherapy, many cancer patients receive radiotherapy treatment. This involves exposing the tumour cells to high-energy radiation to cause alterations that will halt cell division and induce their death. As in the case of chemotherapy, there is preclinical evidence to suggest that cannabinoids might sensitise tumours to this type of treatment. Scott and collaborators, for example, showed that a combination of submaximal doses (i.e. doses that exercise very discreet antitumour effects in themselves) of THC + cannabidiol (CBD) and radiation, caused a dramatic reduction in the growth of glioblastomas generated in mice 6 .

Medical use of cannabis in cancer patients

10. Muñoz E. Cannabinoides y sistema inmune. En: Efectos terapéuticos de los cannabinoides. Ed: Instituto Universitario de Investigación en Neuroquímica de la Universidad Complutense de Madrid. 2017. p. 55-64.

9. Yasueda A, Urushima H, Ito T. Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review. Integr Cancer Ther. 2016;15(1):17-39.