There are currently no recommended medical uses for low-dose CBD. Clinical trial data suggests a benefit of higher dose CBD for some children with a severe form of epilepsy who haven't responded to other drugs. But it's not clear whether the benefits could also have been explained by the fact patients also took Valium. And there were significant side effects reported that were higher in the CBD group.
They also need to understand the legal, professional and regulatory obligations placed on prescribers and dispensers. If products are being bought at the chemist, they may interfere with other drugs or foods. Companies who want to sell such products in Australia will need to focus on bringing their drug development into line with regulatory standards. Time will tell how many can do that.
But so far, no product containing CBD has been approved by the Australian Register of Therapeutic Goods (ARTG), which is a requirement of pharmacist sale. ARTG approval means regulatory quality data on its safety, contaminants, microbial content, shelf-life and efficacy meet the TGA standards and is known and tested in regulatory grade laboratories.
What could low-dose CBD be good for?
Medical professionals should know what they are prescribing or recommending and be able to refer to dose-response data for each compound. They need to know the pharmacology and the drug interactions, the evidence for their use in specific conditions and any negative effects.
There are some local producers exporting cannabis and embarking on clinical trials. Federal health minister Greg Hunt has said Australia is "poised to become a recognised leader in the global supply of the highest-quality medicinal cannabis products".
Here's a first look at how many Australians are taking medicinal cannabis
We don't know whether any cannabis business has applied to the TGA to have its product registered and been rejected due to failures on the safety, efficacy and quality side.
The time and financial costs for drug development to meet the ARTG standards can be significant. Aspiring cannabis companies may not anticipate the difference between selling a product like cannabidiol compared to other products such as toys or clothing.
1 Darkovska-Serafimovska, M., Serafimovska, T., Arsova-Sarafinovska, Z., Stefanoski, S., Keskovski, Z., Balkanov, T., (2018), Pharmacotherapeutic considerations for the use of cannabinoids to relieve pain in patients with malignant diseases, Journal of Pain Research, vol. 11, 837-842.
Terpenes alone have also been shown to produce many of their own positive health benefits, and are recognized by the Food and Drug Administration as safe for human consumption.
Marijuana and hemp are both plants in the cannabis family. Tetrahydrocannabinol (THC) is the cannabinoid compound that is found in the marijuana plant. It is this compound that is responsible for making you “high”. In contrast, the hemp plant contains negligible amounts of THC, which in turn makes it very unlikely to cause any sort of “high”.
Transcending Organics’ CBD oil is produced using only organic, non-GMO and vegan ingredients. Our hemp is grown in the United States using only the most natural of methods: the earth and sun. When the plant is ready for harvest, CBD oil is carefully extracted from the whole plant. From there, it undergoes a process of winterization and short path distillation. Only then, is it in its purest form and ready for use as CBD oil.
Why you should choose Transcending Organics when you buy CBD oil.
It is widely accepted that CBD oil works by way of its interaction with the endocannabinoid system (ECS) of the body. Cannabidiol is thought to bind to the body’s endocannabinoid receptors when the oil is ingested. Once the CBD oil has bound to the receptors in the body, it may enhance the activity of a number of physiological processes.
If you have any further questions, please check our FAQ page or send us an email.
When terpenes are included in CBD oil preparations, they are known to facilitate the ‘entourage effect’. Several studies have demonstrated this synergistic effect, whereby the use of different plant components (in this case, cannabidiol plus terpenes) in conjunction with one another causes an interaction that produces a stronger desired effect. Put simply, the terpenes work with the cannabinoids to help them pass through the bloodstream more efficiently, creating a greater overall effect on the ECS.
How is CBD oil produced?
3 Booz, G., (2011), Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress, Free Radical Biology and Medicine, vol. 51(5), 1054-1061.
Cannabidiol (or CBD as it is otherwise referred to) is a chemical compound that is extracted from either the hemp plant, or cannabis plant, Cannabis sativa. CBD oil is cannabidiol in oil form. CBD is the second most prevalent of over 100 natural compounds found in the cannabis plant.