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cbd brain inflammation

This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic phytochemical present in Cannabis sativa, on the cognitive and emotional impairments induced by bilateral common carotid artery occlusion (BCCAO) in mice. Using a multi-tiered behavioral testing battery during 21days, we found that BCCAO mice exhibited long-lasting functional deficits reflected by increase in anxiety-like behavior (day 9), memory impairments (days 12-18) and despair-like behavior (day 21). Short-term CBD 10mg/kg treatment prevented the cognitive and emotional impairments, attenuated hippocampal neurodegeneration and white matter (WM) injury, and reduced glial response that were induced by BCCAO. In addition, ischemic mice treated with CBD exhibited an increase in the hippocampal brain derived neurotrophic factor (BDNF) protein levels. CBD also stimulated neurogenesis and promoted dendritic restructuring in the hippocampus of BCCAO animals. Collectively, the present results demonstrate that short-term CBD treatment results in global functional recovery in ischemic mice and impacts multiple and distinct targets involved in the pathophysiology of brain ischemic injury.

Keywords: Bilateral common carotid arteries occlusion; Cannabidiol; Neuroplasticity; Neuroprotection; White matter.

Cbd brain inflammation

The secret of the therapeutic use of marijuana lies behind the mechanism of action of marijuana on the brain. The most particular constituent of marijuana is the tetrahydrocannabinol (THC), which is the characteristic substance behind the drug abuse. The second major constituent is cannabidiol (CBD). CBD is not psychoactive and has an effect on the brain circuits that is a lot different from the THC effect.

Introduction

Traumatic brain injuries are heterogeneous in their clinical presentation. The signs and symptoms of a traumatic brain injury can be very vast. The onset of the symptoms may be as sudden as on the spot and time of the injury, or may not appear until weeks following the injury. The symptoms may not appear at all or maybe misleading as people may look fine even though they may act or feel differently. Headache and dizziness accompanied by confusion and fatigue may start immediately after an injury, but subsides over time. There might also be emotional symptoms, the victim might develop frustration and irritability in the general behavior later on after the injury. The severity of the symptoms involved in traumatic brain injury depends on the extent of injury to the head. Due to severe or repeated blows to the head, the injury might result in chronic traumatic encephalopathy. Chronic traumatic encephalopathy, also known as CTE disorder, may cause a wide range of problems in the victim, which may include motor disorders related to speech causing communication and cognition disabilities, irritation, and psychiatric disorders such as depression. The increased intracranial pressure resulting from fluid leakage into the brain tissue due to intracranial hemorrhage may lead to an overall reduction in cerebral blood flow which ultimately leads to necrosis in the tissue. The breakdown of the cerebrovascular endothelium due to the injury causes the dysfunction of the blood-brain barrier. Extracranial manifestations of traumatic brain injury can also result in TBI. Among them, pulmonary disabilities are the most common.

CBD as an anti-dote for Brain Damage

HIE is a medical condition found in newborn babies, which usually occurs when the infant’s brain is accidentally subjected to reduced oxygen supply during birth. The mechanism of hypoxic-ischemic encephalopathy is visible from its name: Hypoxia is a term that explains the reduction in oxygen supply to a tissue due to various causes, ischemia stands for inadequate blood supply to an organ due to vasoconstriction or shock, and encephalopathy means a brain disease that alters the normal brain biology or its function due to abnormalities in its structure. Asphyxiation of the newborn due to any cause mostly results in hypoxic-ischemic encephalopathy, as it most commonly interferes with the supply of blood to the nervous tissue in the newborn. If the blood supply to the brain is altered during its developmental phases, it results in serious birth brain defects in the babies later on in their lives. HIE may also be caused due to strangulation of the umbilical cord around the neck of the baby, thereby causing dangerous strangulation. Or, it may also be caused due to the abnormal stretching of the mother’s pelvis to give birth to the baby. The short width of the pelvis does not give enough room to the baby’s head to come out, which results in compression of the vessels supplying blood to the brain, thereby causing ischemia and gradually leading to hypoxia. This hypoxia can affect different areas of the brain.