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cbd blood pressure reddit

Cbd blood pressure reddit

The study says that they had no way to document whether each participant was a consistent user, meaning any conclusions they jump to regarding consequences of marijuana-use are speculatory at best.

There are multiple angles to this:

Yesterday, news hit over a very tentative study (in a field that's difficult to study given federal status) claiming that marijuana led to significant increases in blood pressure. I've become hypertensive after a lifetime of low blood pressure after using CBD for eight months. That's n=1 I know, but I was wondering what your thoughts were about the study or about your experiences.

A 1200 person study relating to cannabis users is a VERY small sample size.

There are a lot of co-factors in play, too. Did they take into account the varying diets of the participants playing into their overall cardiovascular health? (i.e did they find 1200 taco-bell gorging stoners, or did they find 1200 health-nut cannabis users, or a mix of everything in between?)

Much more thorough research needs to be done before anybody can confidently make the claims these people are.

Cbd blood pressure reddit

Cannabinoids (CBs) are compounds that bind to CB receptors or are structurally similar to compounds that bind to CB receptors. They include endogenously produced compounds (called endocannabinoids), synthetic compounds and phytocannabinoids obtained from the Cannabis sativa plant. There are over 80 known types of phytocannabinoids, the most widely studied of which is Δ 9 tetrahydrocannabinol (Δ 9 -THC or THC), which is responsible for the psychoactive properties of cannabis (4). The other major phytocannabinoid is cannabidiol (CBD), which does not have psychoactive properties. CBD is currently the focus of much research due to its potential in a number of therapeutic areas, as it has been shown to have antiinflammatory, anticonvulsant, antioxidant, anxiolytic, antinausea, and antipsychotic properties (5). A number of preclinical studies have also shown beneficial effects of CBD in a range of disorders of the cardiovascular system (6). A CBD/THC combination (Sativex/Nabiximols, GW Pharmaceuticals) is licensed for the treatment of spasticity in multiple sclerosis, and CBD alone (Epidiolex, GW Pharmaceuticals) has entered an expanded access program in children with intractable epilepsies (Dravet syndrome and Lennox-Gastaut syndrome). Epidiolex has also received orphan designation status for the treatment of neonatal hypoxia-ischaemic encephalopathy.

Introduction

CBD treatment reduced resting systolic blood pressure (SBP) (mean difference –6 mmHg; 95% CI, –1 to –12, P < 0.05, Figure 1A ). Although there was no overall difference in diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) between the 2 groups, post-hoc analysis showed that both DBP and MAP were lower with CBD treatment ( Figure 1, B and C , respectively; P < 0.01), particularly in the latter time points (120–160 min).

Effect of CBD on resting cardiovascular parameters.

Epidemiological studies have shown a positive relationship between long-term stress and the development of cardiovascular disease (1). Factors like social isolation, low socioeconomic status, depression, stressful family and work life, and anxiety are associated with an increased risk of the development and accelerated progression of existing cardiovascular disease. Current European guidelines on the prevention of cardiovascular disease have emphasized the importance of tackling these factors (2). Mental stress induces myocardial ischaemia in patients with stable coronary artery disease, and this appears to be mediated by adrenal release of catecholamines (3).