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cbd biphasic

Cbd biphasic

This kind of biphasic response curve has been studied in a wide variety of substances such as alcohol, nicotine, amphetamines, psychedelics like ayahuasca, and many pharmaceutical drugs. But it can also be found with cannabis’ two most plentiful and medicinally-utilized cannabinoids — THC and CBD.

Biphasic responses have also been noted with CBD for nausea and vomiting relief. In animal studies, CBD decreased nausea and vomiting measures at low doses but seemed to enhance them at high doses. Other biphasic effects such as sedation and immune responses have also been found from CBD.

In terms of dosing, this means that to achieve the effect you are looking for you need to know what the optimal dose is — and specifically what dose is right for you. As we all know with alcohol, sensitivity can vary. One person may feel nothing from a single drink and only reach the happy social part of their response curve after a few drinks. Someone else might take a few sips to reach their ideal point, while a drink or two might send them past their ideal dose and leave them too drunk for comfort.

Evidence for Biphasic Responses with Cannabis

While the biphasic nature of cannabis might be intimidating at first, understanding it can help you better utilize your medicine.

Cannabis can relieve anxiety, but it can also cause it. Cannabis can make you sleepy, but it can also give you energy. Cannabis can relieve pain, but in some cases it can worsen it.

Biphasic Response Curves and Finding the Right Dose

In other words, the ideal dose for any drug with a biphasic response will vary by individual — but each individual will have an optimal dose at the curve’s peak, just before any further increase sends the effect back in the other direction.

One of the most commonly reported uses for medical cannabis, anxiety, also happens to have a highly reported biphasic effect. Some say that cannabis has a calming effect and can relieve their anxiety, while others say cannabis makes them feel more anxious and can create a feeling of paranoia. This is primarily attributed to the biphasic effects on anxiety exhibited by THC, and has been shown experimentally in a few ways.

Cbd biphasic

Cannabis remains the most commonly consumed illicit drug around the world [6], whilst clinical research is nascent, yet rapidly emerging. Research is urgently required due to the large variety of cannabis preparations that are available on both the licit and illicit drug markets (depending on jurisdictions) [1]. Furthermore, both community and laboratory-based studies have demonstrated that the relative quantities of cannabinoids in the plant may directly affect its pharmacological activity when consumed. For example, when taken together with THC, CBD may potentially offset some of the adverse effects of THC, such as memory impairment and paranoia [7, 8]. It has been demonstrated in rodents that high doses of CBD are able to negate some of the anxiogenic response created by THC [9].


As detailed in Table 4, our search revealed a range of studies of cannabinoids (primarily THC) in anxiety models beginning in 1976. Research over this period of 40 + years has revealed conclusions that are inconsistent. Generally, the results indicate that at lower dosages an anxiolytic response for THC is observed, with the opposite being true of higher doses (however as indicate above across differing animal modes, this finding is not always consistent).

Social interaction

Our review of the data revealed 10 studies involving cannabis users consuming whole cannabis preparations or extracts for anxiety (see Tables 1, 2). Included in our review were cross-sectional studies with no demographic limitations. Three studies in particular demonstrated that such use is prevalent, with more than half of the participants in each survey confirming using cannabis for anxiety [50,51,52]. Further, these studies indicate that there is also a significant proportion of people who replaced some or all prescription medication with cannabis use [53, 54]. The majority of participants were recruited online, particularly through social media or through medicinal cannabis suppliers.