There are a variety of ways to take CBD. It can be inhaled, eaten, applied topically to the skin or held under the tongue and then swallowed. However, the body absorbs CBD in different ways, so how it is consumed matters. The method chosen influences how long it takes to be absorbed into the bloodstream and how much CBD is available to be absorbed.
Inhaling CBD has a very effective bioavailability rate. CBD vape products and pre-rolled hemp flower joints are becoming widespread in the convenience market. They are popular and preferred by many because of how rapidly they work. When CBD is inhaled, the lungs absorb the compound immediately. Once CBD passes through the lungs, it quickly enters the bloodstream and circulates through the body. While inhaling CBD is a fast and effective method, it is not for everyone. Some consumers consider CBD to be a part of their wellness routine and worry about the potential adverse health effects of vaping CBD oil or smoking hemp flower.
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Understanding the bioavailability of CBD allows consumers to decide what is important to them in a product. If they want a fun and easy way to take CBD, then CBD gummies or chocolates are ideal. If speed and cost-effectiveness are paramount, then a sublingual oil tincture or vape product may be best. This knowledge also helps retailers understand why offering a variety of forms of CBD is important for meeting customer demand in their stores.
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Δ9-THC is the major psychoactive cannabinoid and mimics the action of the endogenous cannabinoid receptor ligands anandamide and 2-AG by activating both CB1 and CB2 receptors. Due to its binding to CB1 receptors which are specifically present in the central nervous system in areas associated with pain (eg. Spinal trigeminal nucleus, amygdala, basal ganglia and periaqueductal gray), Δ9-THC possesses antinociceptive activity and is hence used as an analgesic agent in certain pain medications. In addition, Δ9-THC has also been shown to be effective in the treatment of glaucoma, nausea, chronic pain, multiple sclerosis, epilepsy and inflammation in several pre-clinical and clinical studies . However, Δ9-THC abuse is a global concern and due to the behavioural and psychological dependence, Δ9-THC has remained a subject of controversy and a largely unproved therapy with limited studies establishing its benefit-to-risk ratio, safety and efficacy for different indications.