Since both CBD and diazepam act through a similar mechanism, when they are taken together, this mechanism may enhance the effects of both drugs. This interaction can lead to severe side effects of both CBD and diazepam and act synergistically to cause toxicity with symptoms like drowsiness, dizziness, confusion, diarrhea, nausea, impaired thinking, decreased appetite, hypotension, and coma.
Diazepam also acts through a similar mechanism that involves positive allosteric modulation of the GABA receptors to exert its anxiolytic effects.
B) Increased Effect (Agonistic Interaction)
Moderate increases in serum concentration of diazepam can lead to side effects like dizziness, drowsiness, headache, confusion, and impaired thinking.
No, it is advisable to take CBD and diazepam together.
A) Slowed Elimination (Metabolic Competition)
Diazepam is used for the treatment of the following conditions:
We hung up the phone, and I ordered nearly his entire product line to see how it would work on me. While I waited for it to arrive, I decided to ask another friend if she was taking CBD. Two years ago, she was diagnosed with Lyme disease, which led to a host of other neurological conditions including neuropathy and fibromyalgia. She was likely in need of pain relief, and she was probably open to it coming from cannabis.
Sometimes there is a delay though, and the ECS doesn’t tell us when to stop stressing or fighting a cold. This could be the result of a deficiency in our own natural cannabinoids, or an overtaxed endocannabinoid system, a dysfunction that could explain the mechanism of post-traumatic stress disorder.
The Placebo effect may not be a simple trick of the mind like we think, though. Last month a feature by Gary Greenberg in The New York Times made clear that it’s still not fully understood, and may be “a biological response to an act of caring” by any healer — a doctor, an acupuncturist, even a shaman — and “that somehow the encounter itself calls forth healing and that the more intense and focused it is, the more healing it evokes.” If Placebo has more to do with the person administering it, could a recommendation from a friend or a salesperson or an online review really be influencing my perception of CBD?
CBD for pain
It sounded an awful lot like herbalism, which I was already, inadvertently practicing. That Holy Basil Leaf, or Tulsi, bedtime tea really does nudge me to sleep, and if you read this scientific review of its benefits , it sounds a lot like the cure-all capabilities of CBD. The author describes it as an “adaptogen,” or “herb that helps with the adaptation to stress and the promotion of homeostasis,” something that “is not widely used in Western medicine.”
This makes sense: conditions like anxiety and stress are often connected with inflammation in the body and CBD, Hopenwasser notes, is “highly anti-inflammatory.” It works this way in mice , at least, and there are a number of small human trials that show that CBD lowers anxiety.
CBD for dinner
I even tried smoking a CBD-rich strain of hemp —because you can pretty much order any form of CBD online—and was sent into even more of a stupor than I’d felt from the oil or capsules. I imagine that the heady, pot-like scent of the terpenes was to thank. But smoking it meant being discreet, something I can’t always do at home with kids.
After the dinner, I called Kennedy to find out more about how his products worked. He was the first to tell me about the innate system in our bodies that creates nearly identical compounds as CBD. Called the endocannabinoid system, it was discovered fairly recently in the 1980s, well after scientists identified cannabinoids in plants. The ones we produce are like the many neurotransmitters in our bodies and operate in concert like our own inner thermostat to maintain a state of homeostasis. If we become upset during an argument, our cannabinoids help bring our mental state back to normal. After our body fights an infection with a fever, the ECS helps brings our body back to a normal temperature. Remarkably, as the author of a book named Healing with CBD , Eileen Kocienzsky, explained, we have more endocannabinoid receptors than any other type in our body.