Drug metabolism determines the rate at which the body processes medications and other therapeutic compounds into their individual metabolites and how long they can stay in your system.
Any therapeutic substance that relies on the CYP450 system can be potentially affected by CBD. A common indicator for such interaction is when your medication has a grapefruit warning on the bottle. However, this is by no means a solid point of reference, and you should always check with your doctor and pharmacist before taking the two compounds together.
There is no known interaction between CBD and antibiotics, although these interactions may occur if an antibiotic is metabolized through the cytochrome P450 enzyme system. Some studies indicate that taking CBD and antibiotics together may amplify the effects of one another without any negative side effects. However, more research is needed to confirm these findings on a larger scale.
How Is CBD Metabolized?
Let’s start with the don’ts.
Below you’ll find the dos and don’ts of using CBD along with medications.
Contraindications for Taking CBD with Medications
Your email address will not be published. Required fields are marked *
A consultation with a doctor experienced in CBD and cannabis use can help you establish the right routine for your medications and supplements to avoid potentially negative interactions. Some compounds work synergistically with CBD, so asking your doctor can help you maximize the effect of your treatment.
Therefore, the risk of experiencing adverse side effects linked to ibuprofen use may increase when a person takes the drug in conjunction with CBD.
For instance, depending on a drug’s half-life (and the dose of the drug), it has the potential to inhibit liver enzymes for a variable timeframe. Therefore, liver enzymes could regain sufficient function by the time the person takes the second drug.
As one of more than 100 cannabinoids found inside the cannabis plant, CBD offers many potential health benefits without causing users to feel high. The primary difference between CBD and ibuprofen is how they interact with pain response pathways. For example, CBD interacts with CB2 receptors, while ibuprofen blocks the COX-2 from producing extra prostaglandins.
How Does CBD Interact with Ibuprofen?
Ibuprofen is one of the most common non-steroidal anti-inflammatory drugs (NSAIDs), first discovered in 1961. Today, it’s an active ingredient in numerous over-the-counter pain-relief drugs, including household names like Motrin and Brufen. Ibuprofen is very effective at eliminating most forms of pain that result from inflammation. It also works well as a fever reducer.
Let’s take a look.
Dosing and Timing Could Influence How CBD Interacts with Ibuprofen (And Other NSAIDs)
While taking low amounts of ibuprofen and CBD will likely not produce severe adverse effects on the body, more research is needed on the topic. In addition, due to interaction with enzyme activity, there is the potential that CBD may either intensify or reduce the effects of ibuprofen.
The risk of experiencing adverse drug interactions may be lower if you consume ibuprofen and CBD at different times of the day.
Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included
While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.
CBD can alter the effects of other drugs
CBD has the potential to interact with many other products, including over-the-counter medications, herbal products, and prescription medications. Some medications should never be taken with CBD; the use of other medications may need to be modified or reduced to prevent serious issues. The consequences of drug interactions also depend on many other factors, including the dose of CBD, the dose of another medication, and a person’s underlying health condition. Older adults are more susceptible to drug interactions because they often take multiple medications, and because of age-related physiological changes that affect how our bodies process medications.
Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
Doubling up on side effects
Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.