The article is by Sean McAllister, Lilliana Soroceanu, and Pierre-Yves Desprez of California Pacific Medical Center Research Institute. It ran March 30 in the Journal of Neuroimmune Pharmacology, and has not gotten the attention it deserves. Why is it that so many significant journal articles get downplayed and trivial ones often trumped up in the corporate media?
Thank you so much for your thoughtful and insightful comments. I read the McAllister paper on a flight to the Bay Area. As I read about the potential adverse interaction of antioxidants with CBD, two patients came immediately to mind. Both of these patients have stage IV prostate cancer with significant bony metastases and PSA levels greater than 100. One of the patients, despite up to 300 mg of CBD daily (in addition to 100 mg of THC) has continued to show increasing levels of PSA. This patient takes over 25 supplements daily, most of which have significant antioxidant activity. As I read the article a light went off in my head…. an epiphany of sorts…. that his failure to respond might be related to his antioxidant use. I have already advised him to stop his antioxidants. From this 2011 paper http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410650/ by McAllister: “We determined that the ROS scavenger, α-tocopherol (TOC), could reverse the ability of CBD to inhibit the proliferation of MDA-MB231 cells. Moreover, we found that TOC could also significantly reverse the ability of CBD to inhibit the invasion of MDA-MB231 cells and to down-regulate Id-1 protein expression. In agreement with the experiments utilizing TOC, CBD led to a direct increase in ROS formation, an increase that was reverted upon co-treatment with TOC. These data suggest that production of ROS by CBD can lead to the inhibition of both human breast cancer cell proliferation and invasion, in part, through the down-regulation of Id-1 gene expression.” Down regulation of Id-1 gene expression appears to be one of the most important mechanisms involved in not only killing CBD responsive cancer cells, but also in preventing these cancers from metastasizing. In my opinion. Anything that interferes with this process should be avoided. In this 2015 paper http://www.ncbi.nlm.nih.gov/pubmed/25590811 by Singer, enhancement of reactive oxygen species (ROS) led to robust antitumor effects that included decreased glioblastoma stem cell survival, decreased self-renewal, and decreased invasion. Over the past several days I’ve given this matter considerable thought. My initial admonition to stop all anti-oxidants may have been in over reaction. Curcumin, while having antioxidant activity, also has significant anticancer activity and is probably a worthwhile supplement. Medicinal mushrooms, including Turkey Tail, would also fall into this category. That said, I still believe the principle of parsimony would apply when adding antioxidants to CBD cancer therapy. As Dr. Russo said in his SCC presentation yesterday, perhaps the mild antioxidant activity of CBD itself is sufficient. Again, thank you Dr. Sulak for your insightful input. Through these types of dialogues, we all learn and are better able to help our patients. Joe D.
First the warning: The attached review article is seminal and its main message needs to be widely disseminated, in my opinion. Many people who use CBD as part of their treatment for cancer are also taking a lot of supplements, many of which have antioxidant properties. Antioxidants appear to reverse the cancer-inhibiting properties of CBD. Vitamins C and E, curcumin, CoQ10, etc., they all need to be stopped when CBD is used for cancer, in my opinion.
Response from Dr. Goldstrich December 8, 2015:
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.