At a minimum, the evidence at this point suggests that grapefruit warnings on medications should also apply to CBD. And it’s important to check with your doctor before taking CBD, especially if you’re taking other medications.
A low dose of a med could become a high dose if it’s not properly broken down and eliminated. A high dose of a med could become a dangerously high dose, or even an overdose. Drugs with a narrow “therapeutic window” (they must stay within a certain blood-concentration range) are especially susceptible.
Apart from a short list of possible side-effects, bigger concerns revolve around how CBD interacts with other drugs. Here’s a brief breakdown of possible risks if you’re thinking of trying it out.
One of the big problems with CBD at the moment is we don’t really know yet which drugs are affected the most, and it’s difficult to identify exact levels of risk because the research has a lot of catching up to do after decades of science-blocking illegality. But since the compound appears to exert similar effects as grapefruit, caution is needed.
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Interest in cannabidiol (CBD) is exploding. Now that major retailers are carrying CBD products, plus an enormous selection online, curiosity is only going up. But we also need some healthy skepticism and caution to balance out the exuberance. CBD research is still in the early stages, and marketing is predictably outpacing facts. Concerns about safety, among other topics, are getting lost in the hype.
CBD is similar to grapefruit in that it also binds with those enzymes, but research suggests that it’s possibly even more potent because it binds in multiple parts of the gut and liver (grapefruit mainly affects enzymes within the small intestine). Once an enzyme has been inhibited, the effect isn’t immediately reversed. It can take days for enzyme function to return to baseline and start the process again.
What CBD and grapefruit have in common
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What’s the best path forward?
The enzymes that both grapefruit and CBD inhibit are thought to break down a significant percentage of prescription and over-the-counter medications, so the potential for problems could be high.
There are no other indications of increased side effects or decreased drug effectiveness when taken with CBD.
Does CBD Interact With Atorvastatin?
Atorvastatin has many potential side effects which are dose-related.
Side Effects Of Atorvastatin
These mechanisms help lower the bad lipid particles from the blood like cholesterol, LDL, triglycerides, and apo-B and increase HDL, the good lipid.