Cannabis is widely used recreationally and for symptomatic relief in a number of ailments. However, cannabis has been implicated as a risk factor for the development of psychotic illness. For forty years researchers have utilised intravenous preparations of Δ(9)-THC, as well as several other phytoca … Can You Inject Cbd Oil – Smokymountainsk8way.com fat 19 gummy worm Can Cbd Oil Cure Brain Cancer, 2022-09-09 Top 5 Best can you inject cbd oil With High Quality. These monks all knew that he
Cannabis in the arm: what can we learn from intravenous cannabinoid studies?
Cannabis is widely used recreationally and for symptomatic relief in a number of ailments. However, cannabis has been implicated as a risk factor for the development of psychotic illness. For forty years researchers have utilised intravenous preparations of Δ(9)-THC, as well as several other phytocannabinoids, in a laboratory setting. The intravenous route has the most reliable pharmacokinetics, reducing inter-individual variation in bioavailability and is well suited for the delivery of synthetic compounds containing a sole pharmacological moiety. Given the association between cannabinoids and psychotic illness, there has been a resurgence of interest in experimental studies of cannabinoids in humans, and the intravenous route has been employed. Here in a critical review, we appraise the major findings from recent intravenous cannabinoid studies in humans and trace the historical roots of this work back to the 1970’s.
Manwell LA, Ford B, Matthews BA, Heipel H, Mallet PE. Manwell LA, et al. J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):112-9. doi: 10.1016/j.vascn.2014.06.004. Epub 2014 Jun 21. J Pharmacol Toxicol Methods. 2014. PMID: 24956154
Milman G, Bergamaschi MM, Lee D, Mendu DR, Barnes AJ, Vandrey R, Huestis MA. Milman G, et al. Ther Drug Monit. 2014 Apr;36(2):218-24. doi: 10.1097/FTD.0b013e3182a5c446. Ther Drug Monit. 2014. PMID: 24067260 Free PMC article. Clinical Trial.
Manwell LA, Charchoglyan A, Brewer D, Matthews BA, Heipel H, Mallet PE. Manwell LA, et al. J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):120-7. doi: 10.1016/j.vascn.2014.06.006. Epub 2014 Jun 25. J Pharmacol Toxicol Methods. 2014. PMID: 24973534
Goullé JP, Guerbet M. Goullé JP, et al. Bull Acad Natl Med. 2014 Mar;198(3):541-56; discussion 556-7. Bull Acad Natl Med. 2014. PMID: 26427296 Review. French.
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Singh K, Jamshidi N, Zomer R, Piva TJ, Mantri N. Singh K, et al. Int J Mol Sci. 2020 Aug 29;21(17):6265. doi: 10.3390/ijms21176265. Int J Mol Sci. 2020. PMID: 32872551 Free PMC article. Review.
Ganesh S, Cortes-Briones J, Ranganathan M, Radhakrishnan R, Skosnik PD, D’Souza DC. Ganesh S, et al. Int J Neuropsychopharmacol. 2020 Dec 3;23(9):559-570. doi: 10.1093/ijnp/pyaa031. Int J Neuropsychopharmacol. 2020. PMID: 32385508 Free PMC article.
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Andre CM, Hausman JF, Guerriero G. Andre CM, et al. Front Plant Sci. 2016 Feb 4;7:19. doi: 10.3389/fpls.2016.00019. eCollection 2016. Front Plant Sci. 2016. PMID: 26870049 Free PMC article. Review.
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