Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included
Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.
CBD can alter the effects of other drugs
While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.
Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.
Does the form of CBD matter?
Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.
Cannabidiol (CBD) comes from the cannabis plant and is usually served in the form of hemp extracts mixed with a carrier oil. CBD has been shown to have positive benefits on stress, anxiety , and depression . The relief can also translate to better sleep . These benefits of CBD not only help you catch more ZZz’s, but it can also benefit other health conditions and overall wellness.
When taking CBD and melatonin together, this can be a powerful duo for getting you back into your body’s natural sleep rhythm. As you can see, they are both considered safe. Both have been proven to affect sleep. But when taken together , they may be even more effective.
As a result, you will find many CBD gummies, tinctures, vapes, and topicals out there making false claims and purity and doses. Stick with high-quality, third-party tested CBD products from Juna World.
CBD Oil for Sleep
Talk to your doctor before taking cannabidiol. You may experience increased side effects if CBD interacts with:
Before adopting melatonin into your sleep routine, there are a few things to be aware of.
Alleviating stress, anxiety, and depression may be a better method of addressing your underlying sleep issues.
CBD Side Effects and Interactions
Taking melatonin may have some negative interactions and other substances. Some of these interactions include:
When it comes to taking melatonin, less is more. Believe it or not, you can overdose on melatonin. Since it is a natural hormone that can become out of balance, it is possible to tip that balance to where you have taken too much. An overdose can daytime sleepiness, nightmares, vivid dreams, or any of the following effects: