Can I take CBD and Ibuprofen together? If you’ve ever asked this question, here’s the answer you’re looking for. A lot of people take CBD oil with ibuprofen for pain relief. But is it safe? Here, we explain everything you need to know.
Can I Take CBD and Ibuprofen Together?
A few years ago, painkillers were the only solution against everyday pains, such as headaches, back pain, etc. Then, CBD came along, and people turned towards this holistic pain relief method.
However, some people are still smitten by the idea of using painkillers but also want to give natural approaches a try. If you can relate, you might have asked: can I take CBD and Ibuprofen together?
Using CBD with medication is not just unsafe, but it also lowers the cannabinoid’s effectiveness. Some users might want to combine CBD with the medication to get instant relief. But is it safe? Does it even work?
Below, we answer all these questions while discussing the interaction of CBD with medicinal drugs.
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How Does Ibuprofen Help In Pain Relief?
Ibuprofen is one of the most commonly used painkillers in the world. It was discovered in 1961 and since then has become a widely-sold NSAID.
It’s available in a ton of household names, such as Brufen. As for effectiveness, the medication is quick to relieve most pains, even those resulting from inflammation. In some cases, it may also help reduce fever.
The medicine works by blocking a certain hormone called prostaglandin. The hormone is not secreted by a gland, unlike all other hormones in the body. Instead, it is only released at the site of need.
Typically, prostaglandins arrive at the site of tissue damage or infection.
Ibuprofen limits the working of the cyclooxygenase 2 enzymes. Owing to this, the prostaglandin release slows down, leading to lowering pain and inflammation. However, users must remember that Ibuprofen comes with its share of side effects.
Some of them include:
- High blood pressure
- Heart attack
Most of these side effects manifest when the medication is used in a large amount.
How Does CBD Differ?
Humans have used cannabis for centuries against different ailments, but it was only recently that scientists realized that CBD is a non-intoxicating compound of the plant. The discovery was considered a revolution because it allowed us to use the plant without a high.
The pain-relieving effects of Ibuprofen and CBD are similar in the sense that they both interact with certain receptors. However, while Ibuprofen stops enzyme production, CBD interacts with the CB1 and CB2 receptors.
At the moment, there’s not a lot of information about the precise working of CBD. Experts believe that it might affect the pain signaling pathways, preventing message transmission.
Can I Take CBD and Ibuprofen Together?
Currently, there’s not enough information about the interaction of CBD with medication. However, experts theorize that the compound hinders the working of medicinal drugs and might render them useless for the body.
Although there’s no detailed information on the subject, CBD drugs interactions fall into two categories:
- The cannabinoid might act as an obstacle to the effectiveness of the drug.
- The cannabinoid might bind with the drug, leading to chaos in the body.
In both cases, the results are not pleasant. On the one hand, you’re not getting any benefits from the medicine. On the other, you’re putting your body at the risk of unwanted effects.
The Journal of Neurology Research reports the absence of any interactions between Ibuprofen and CBD. However, that doesn’t mean you can take the two together.
At the moment, there isn’t enough research about CBD drug interactions to explain or figure out the cannabinoid’s effect on the body when used in conjunction with medicinal or recreational drugs.
Can CBD Oil Be Taken with Ibuprofen? [What the Science Says]
Pain and inflammation are part of life. So if you’re someone who struggles with pain often, then ibuprofen is probably a good friend of yours. In recent times, however, more and more folks are turning to CBD oil to help manage pain in a more natural way.
Therefore, this raises the question – can CBD oil be taken with ibuprofen?
Let’s take a look.
CBD Oil vs. Ibuprofen: How Does Ibuprofen Manage Pain?
Ibuprofen is one of the most common non-steroidal anti-inflammatory drugs (NSAIDs), first discovered in 1961. Today, it’s an active ingredient in numerous over-the-counter pain-relief drugs, including household names like Motrin and Brufen. Ibuprofen is very effective at eliminating most forms of pain that result from inflammation. It also works well as a fever reducer.
Ibuprofen works by blocking a specific type of hormone known as prostaglandin. Unlike normal hormones, prostaglandins are not secreted by any gland. Instead, they form via chemical reactions at the site where they’re needed. Typically, this is a site where there has been an infection or tissue damage (hence the resulting pain, inflammation, etc.).
Ibuprofen limits the number of enzymes produced by cyclooxygenase-2 (COX-2). This results in decreased prostaglandin release when the body experiences injury, leading to lowered inflammation and pain.
It’s important to note that ibuprofen comes with some potential side effects. Some of these include dizziness, high blood pressure, and ulcers (stomach bleeding).
What Makes CBD Different?
Cannabis has been consumed for centuries to help alleviate pain, and now scientists are aiming to find the link between cannabinoids and their anti-inflammatory and analgesic (pain-relieving) potential.
As one of more than 100 cannabinoids found inside the cannabis plant, CBD offers many potential health benefits without causing users to feel high. The primary difference between CBD and ibuprofen is how they interact with pain response pathways. For example, CBD interacts with CB2 receptors, while ibuprofen blocks the COX-2 from producing extra prostaglandins.
The analgesic mechanism of CBD is complex and not as well understood as that of ibuprofen. However, it appears to offer pain relief by inhibiting the action of neurotransmitters.
Although CBD interacts with pain response pathways in a unique way to ibuprofen, it appears to have similar pain-relieving properties.
According to a 2018 publication in Frontiers of Pharmacology, cannabinoids (like CBD) have an inhibitory effect on neurotransmitters and neuropeptides that are involved in the “activation of descending inhibitory pain pathways, [as well as] reduction of neural inflammation.”
So, as you can see, the differences between CBD and ibuprofen for pain relief are quite distinct. Of course, ibuprofen and CBD are often not enough by themselves to combat pain completely. This leads many to want to use the two drugs in combination. But is using ibuprofen and CBD oil together safe?
How Does CBD Interact with Ibuprofen?
Currently, not much is known about how CBD could interact with other medications – including ibuprofen. More research is needed, but research has shown that CBD poses inhibitory action on some enzymes that galvanize drug metabolism.
Therefore, the risk of experiencing adverse side effects linked to ibuprofen use may increase when a person takes the drug in conjunction with CBD.
When looking at CBD drug interactions, there are two basic categories:
- Those that can create a dangerous interaction and, therefore, should never be used in conjunction with CBD
- Those that require you to be cautious when using the two together
Ibuprofen falls into the second category – you should be cautious when using it together with CBD because they are both metabolized by the same process in the liver. Since taking both may either increase or decrease their concentration depending on how quickly liver enzymes can break down each drug, the overall effects of the ibuprofen may be reduced or intensified.
Dosing and Timing Could Influence How CBD Interacts with Ibuprofen (And Other NSAIDs)
The time that you take both CBD and ibuprofen may influence how the two drugs interact in your body. Spacing out doses of medication helps to reduce the workload on the liver.
For instance, depending on a drug’s half-life (and the dose of the drug), it has the potential to inhibit liver enzymes for a variable timeframe. Therefore, liver enzymes could regain sufficient function by the time the person takes the second drug.
The risk of experiencing adverse drug interactions may be lower if you consume ibuprofen and CBD at different times of the day.
The dosage used may also have an effect on any potential interaction of ibuprofen with CBD. When a person uses large amounts of CBD and ibuprofen together, there may be an increased risk of danger (such as increased stomach bleeding). Some medical experts have speculated that taking low amounts of CBD doesn’t seem to affect the way the liver metabolizes ibuprofen.
Of course, it’s worth noting that everyone responds differently to drugs. Some individuals may be sensitive to certain substances, while others may have little to no reaction. Ultimately, how the body processes medication – and its effect – is very much influenced by genetics, body size, age, and so on.
Final Thoughts on CBD and Ibuprofen
While taking low amounts of ibuprofen and CBD will likely not produce severe adverse effects on the body, more research is needed on the topic. In addition, due to interaction with enzyme activity, there is the potential that CBD may either intensify or reduce the effects of ibuprofen.
Ultimately, it’s best to consult with a doctor or healthcare provider before using CBD oil in conjunction with ibuprofen. They will help you decide whether it’s safe to use CBD oil and may also be able to offer medical advice regarding the dosage of CBD oil that may be effective without causing any adverse effects.