Can I Give My Dog Prednisone And CBD Oil

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What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some. Prednisone may be used on dogs to help relieve shock or asthma, but with caution as the US Food & Drug Administration (FDA) hasn't approved it yet for vet use.

Can my Dog take CBD Oil While Taking Other Medications?

With the pet CBD market industry exploding globally, it’s no surprise that we need to look out for any drug interactions. What many people don’t know is that dog CBD oil can interact with other medications by either enhancing the effect, or by interfering with the metabolism of some.

In this blog, we’ll discuss why it’s important to consult with your veterinarian first before using CBD pet products.

Not only is this important so that you can get a proper diagnosis for a medical condition, but your veterinarian will be able to discuss any possible side effects if CBD is used together with other pet meds.

Here’s what you need to know to fully protect your pet, and to make sure that there are no drug interactions.

CBD can alter the way your dog processes certain medications

Yes, although cannabidiol (CBD) is a natural supplement that is beneficial for numerous health conditions in pets, as well as for chronic pain, insomnia, depression , and anxiety, CBD does have the potential to interact with certain medications.

CBD is derived from the hemp plant, yet it can also come from the marijuana plant. CBD hardly ever contains delta-9-tetrahydrocannabinol (THC), which is the compound that gives marijuana its “high” effect. High-quality CBD is non-toxic and considered safe for pets and humans alike.

There are almost no side-effects, apart from those coming from a low-quality CBD oil that may contain contaminants. It’s always best to look out for the compromised quality of some CBD oils.

You’ll need to discuss with your veterinarian all supplements, over-the-counter meds and prescription meds that your pet may be taking. Today research continues to demonstrate how effective CBD oil is for pets, yet one still needs to examine how it can interfere with the metabolism of pet meds and other supplements.

Benefits of CBD Oil for Dogs

Cannabidiol (CBD) extract is quickly gaining popularity as a natural alternative for managing pain, inflammation, and a variety of medical conditions, including epilepsy. However, recent reports have called into question the safety of CBD when used together with other pet meds. It’s also good to note that using a compromised quality or low-quality CBD oil raises the risk of side effects.

A recent 2019 study by the University of Korea, demonstrates that the CBD anti-cancer protein shows potential in killing tumor cells. The researchers tested the synergistic effect of CBD with a cancer destroying protein called TRAIL. (TNF related apoptosis- inducing ligand.)

The study concluded that TRAIL and CBD created apoptosis separately in colorectal cancer cells. The researchers also found that together, both reduced cancer cells a lot. “ To the best of our knowledge,” they wrote, “this is the first report that cannabidiol induces significant TRAIL-induced apoptosis of colorectal cancer cells,” noting that earlier reports suggested that a different protein response was responsible for cancer-cell death.” via MDPI Journals.

FDA & CBD

The FDA has also tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to have. We have also heard reports of CBD potentially containing contaminants (e.g., pesticides, heavy metals); we are looking into this.

Some cannabis products are also being marketed as pet food and health products for animals. The FDA has not approved cannabis for any use in animals and recommends pet owners talk with their veterinarians about appropriate treatment options for their pets.” via FDA, 2019.

Blood Pressure and CBD Oil

High doses of CBD oil may potentially drop blood pressure resulting in lightheadedness and possibly dizziness in people. It’s always best to consult with your veterinarian for the best advice prior to purchasing a CBD product. That said, the positive side of CBD oil use is that it may be good for patients with high blood pressure. CBD together with regular exercise and a healthy diet help to regulate hypertension.

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A 2017 study by Dr. K Jadoon on CBD and its effects on blood pressure demonstrated the following:

The study concludes that “acute administration of CBD reduces resting BP and the BP increases stress in humans, associated with increased HR. These hemodynamic changes should be considered for people taking CBD. Further research is required to establish whether CBD has a role in the treatment of cardiovascular disorders.”

CBD Oil Interacts with Anti-Seizure Meds

A study researching CBD interactions with seizure meds in people added that “ Because all of the participants are also taking other seizure drugs while they are receiving the investigational therapy, investigators checked the blood levels of their other seizure drugs to see if they changed. “With any new potential seizure medication, it is important to know if drug interactions exist and if there are labs that should be monitored while taking a specific medication,” said lead author Tyler Gaston, MD,” via Science Daily.

Dr. Gaston and her colleagues found that there were significant changes in levels of the drugs clobazam (and its active metabolite N-desmethylclobazam), topiramate, and rufinamide in both adults and children, and zonisamide and eslicarbazepine in adults only.

Except for clobazam/desmethylclobazam, however, the drug levels did not change outside of the normally accepted range. In addition, adult participants in the study taking clobazam reported sedation more frequently.

Additionally, when seizure patients were using valproate, they added that “Tests also showed that participants taking valproate and CBD had higher ALT and AST (liver function tests) compared with participants not taking valproate.

Very high ALT and AST indicate abnormal liver function, but significant ALT and AST elevation occurred only in a small number of participants (4 children and 1 adult), and the levels returned to normal after discontinuation of valproate and CBD.”

The study concludes that “The findings emphasize the importance of monitoring blood levels of antiepileptic drugs as well as liver function during treatment with CBD. “

A perception exists that since CBD is plant based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of,” said Dr. Gaston.”

Cytochrome P450

CBD as a natural supplement does not cause a “high” in pets, but may cause a reaction when used together with anti-seizure meds. Cannabinoids have been shown to inhibit cytochrome P450 enzymes by using up these enzymes, and by inhibiting how other enzymes work.

When cannabidiol oil is consumed by dogs in large amounts, a large group of enzymes may be altered in the same way that grapefruit alters enzymes.

Most pet meds are metabolized in the liver via certain enzymes that are made in it. CBD works in the same way that grapefruit does, and may use up all the enzymes and also alter the effectiveness of pet meds.

NSAIDs and Corticosteroids

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are a class of drugs commonly used to control pain and inflammation in dogs. NSAIDs help many dogs lead a life that is more comfortable for them, but what about interactions with CBD oil? CBD oil has the potential to make pet meds less effective.

That said, pet parents should take every precaution to ensure that there are no interactions with any of their pet meds or supplements, and even NSAID’s, corticosteroids, pet herbal supplements and vitamins. The potential for adverse reactions will also depend on the body chemistry of your pet and the dose of the prescription or supplement.

Administer CBD oil 2 hours before or 2 hours after giving pet meds or supplements.

NSAID’S include the following:

  • Rimadyl
  • Metacam,
  • Deramaxx,
  • Etogesic

Meds like Gabapentin when taken together with CBD can cause lethargy in pets. It’s important to discuss CBD use with your veterinarian prior to administering.

Common corticosteroids include the following:

  • Prednisone
  • Triamcinolone,
  • Dexamethasone,

The most common symptoms when using these are gastrointestinal issues like lack of appetite, vomiting, diarrhea, and even ulcers. We all know that pets cannot take both NSAID’s and corticosteroids at the same time, but what about cannabidiol oil and NSAID’s and corticosteroids?

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CBD oil can also enhance the effectiveness of certain drugs and one may be able to lower the dose of pet meds or therapy when using CBD oil. Pet meds that are used for pain relief need to be administered carefully when using them together with CBD oil.

Natural Alternatives to Prednisone for Dogs – August 2022

Prednisone is a corticosteroid used in alleviating symptoms of skin conditions, breathing disorders, arthritis, auto-immune and allergic reactions like hives (13 ) . It suppresses the immune system and inhibits the release of inflammation-causing substances in the body.

Patients’ immune response to Prednisone is positive. It treats auto-immune diseases like ulcerative colitis (inflammatory bowel disease), lupus, and psoriasis.

This corticosteroid also treats central nervous system disorders and hormonal disorders such as Addison’s disease, a rare disorder where the sufferer’s adrenal gland is unable to produce ample amounts of cortisol and aldosterone hormones (14 ) .

Prednisone vs. Prednisolone

Prednisone and prednisolone are both synthetic glucocorticoids (steroid hormones). They can treat the same auto-immune, skin, central nervous system, and hormonal conditions. However, Prednisone still needs to be converted by liver enzymes before it can take effect (15 ) .

Doctors are more likely to prescribe prednisolone to patients who have severe liver diseases or cats as they lack the enzyme needed to break prednisone to prednisolone.

Can Prednisone be Used on Dogs?

Prednisone may be used on dogs but must be administered with caution (16 ) .

It is often used to treat Addison’s disease by supplementing dogs with glucocorticoids that their own body is unable to produce.

Prednisone can also treat dogs for the following conditions (17 ) :

  • Asthma
  • Some cancer forms
  • High blood calcium levels (hypercalcemia)
  • Central nervous system disorders
  • Skin disease
  • Arthritis
  • Shock

An article by Dr. Tammy Hunter, DVM and Dr. Ernest Ward, DVM reveals that even if Prednisone and Prednisolone are synthetic or human-made corticosteroids, they are more potent than those that are naturally found in the body. Their effects last longer, too (18 ) .

Dogs on Prednisone should be monitored carefully for side effects. According to Hunter and Ward, the benefits outweigh the risks when using Prednisone on pets (19 ) .

Few side effects will occur when the medication is used correctly.

Similar to many drugs in veterinary medicine, despite Prednisone’s benefits, its use in animals has not been approved by the U.S. Food and Drug Administration (FDA) (20 ) .

Prednisone Dosage for Dogs

If Prednisone is administered for its anti-inflammatory effects, the standard dosage for Prednisone in dogs is 0.5mg per kilogram. If it is used to treat immune system disorders in dogs, the dosage is 1mg per kilogram (21 ) .

When it comes to dosing Prednisone, use as much as is required to treat the symptoms but as little as possible to reduce the chances of the dog experiencing severe side effects (22 ) .

As soon as the dog’s condition improves, the slow tapering of the pet off Prednisone is suggested (23 ) .

According to Dr. Rania Gollakner, BS, DVM, in about 1 to 2 hours, Prednisone should take effect, and significant improvements in the dog should follow (24 ) .

Best combined with pet food, Prednisone comes in tablet, injectable, or liquid form (25 ) .

Dr. Barbara Forney recommends that Prednisone be given to dogs once daily, preferably in the morning (26 ) .

Side Effects of Prednisone on Dogs

Potential short-term side effects of Prednisone on dogs, especially on those who are taking it for its immunosuppressive properties are as follows (27 ) :

  • Increased thirst
  • Excessive urination
  • Increased appetite

When Prednisone is given at higher doses or for long periods of time, more severe and long-term side effects may be observed (28 ) .

  • Increased risk of infection
  • Altered behavior including aggression
  • Inhibited growth especially in young dogs
  • Development or worsening of diabetes
  • Cushing’s disease
  • Vomiting
  • Diarrhea
  • Ulceration of the digestive tract
  • Lethargy
  • Delayed wound healing

A study conducted in 2015 revealed that dogs under corticosteroid treatment had shown adverse behavioral changes (29 ) .

It is also important to note that Dogs who are suffering from infections like fungal infections should not be given Prednisone. Corticosteroids will bring these out, even latent infections (30 ) .

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Prednisone should also not be taken with drugs prone to causing ulcers, such as nonsteroidal anti-inflammatory drugs (NSAIDs), as doing so can result in stomach ulcers.

Natural Alternatives to Prednisone for Dogs

Because of Prednisone’s side effects on a dog’s body, some pet owners are turning to natural alternatives for their pet’s medical conditions.

Yucca Schidigera and Dogs

For joint pain and inflammation, Yucca Schidigera is a recommended natural alternative. Its extracts have anti-arthritic and anti-inflammatory effects (31 ) .

Yucca is a medicinal plant from Mexico. It is available in tablet form.

Turmeric and Dogs

Instead of treating dogs with anti-inflammatory drugs, turmeric is a good alternative. A 2009 study shows that turmeric, particularly its curcumin compound, can be used to treat inflammation (32 ) .

Aside from being anti-inflammatory, turmeric also has antibacterial, antitumor, and antioxidant properties (33 ) .

CBD Oil and Dogs

Another natural alternative to Prednisone for dogs is CBD (Cannabidiol) oil, a non-psychoactive cannabinoid.

Most CBD benefits are reported on humans, especially its positive effects on epilepsy, anxiety, and different types of chronic pain (34 ) . However, it is suggested that the system that regulates the functions of cannabinoids, the endocannabinoid system (ECS), is the same for all animal species except insects (35 ) .

If the ECS of a human and a dog work the same way, it is suggested that CBD oil can be given to dogs as well.

According to a 2017 article (36 ) , CBD shares metabolic pathways with anti-inflammatory drugs. Thus, it can help alleviate the inflammatory conditions Prednisone treats.

A 2018 study concluded that dogs suffering from osteoarthritis experienced a significant decrease in pain when they were administered with CBD oil. They were also perceived to be more comfortable and active (37 ) , with no adverse effects when they were observed short-term.

Prednisone treats shock in dogs because of its ability to improve circulation. Similarly, studies have shown that CBD reduces high blood pressure and heart rate in stressful situations (38 ) .

The 2017 study also revealed that CBD increases cerebral blood flow (39 ) .

CBD can also help treat a dog’s itchy skin. Its protective role of the ECS could help reduce allergy in the skin (40 ) .

A study also discusses CBD’s role as a potent inhibitor of cancer growth and spread. The research also suggests that CBD can be combined with classical chemotherapeutic agents (41 ) .

Once CBD is used alongside chemotherapeutic agents, their dose and toxicity are reduced while the efficacy is maintained.

While Prednisone alleviates asthma symptoms, CBD could also be as effective.

A study in 2015 states that CBD’s immunosuppressive and anti-inflammatory properties could help in the treatment of asthma (42 ) .

Despite these benefits, CBD also has side effects like dry mouth, lowered blood pressure, and drowsiness (43 ) .

The U.S. Food and Drug Administration has not approved CBD use, so a dosing chart for dogs is not available.

Dog owners should administer small amounts of CBD at first and then monitor its effects. CBD can be given orally, combined with pet food, or used in massages.

Before including CBD in the dog’s regimen, it is recommended that pet parents inform their veterinarian first.

CBD and Prednisone

CBD and Prednisone should not be taken together. The liver enzyme cytochrome P450 metabolizes Prednisone for it to take effect on the body.

A study shows that CBD inhibits the enzyme system, thereby raising risks like amplifying Prednisone’s side effects (44 ) .

Conclusion

Prednisone can be used on dogs. Short-term use already presents side effects, but the more concerning ones come from large doses and long-term use of the drug.

For inflammation in dogs, the dosage of Prednisone is 0.5mg per pound. For immune system disorders, the dosage is 1mg per pound.

Using Prednisone on pets for an extended period of time could bring about adverse effects; hence, natural alternatives like CBD oil are recommended.

CBD oil helps treat the symptoms Prednisone is used for sans the adverse effects. These symptoms include inflammatory conditions, arthritis, shock, skin conditions, cancer, and asthma.

Pet owners should consult with their veterinarian before giving CBD to their dogs.

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