But what if you could skip the cosmetic surgery — which costs, on average, $8,005 — and sculpt your face from the sofa instead? Social media platforms like TikTok and Instagram are rife with beauty tutorials offering ways to achieve a more lifted look through facial massage, at-home micro-current devices and even face tape. (Yep, it’s exactly what it sounds like. Tape. On your face.)
Can anything provide face-lift-level results at home?
Sure, you can improve skin texture through laser resurfacing at a dermatologist’s office, or create the illusion of a lift with injectable fillers. You can even tighten trouble spots with radio-frequency therapy, a nonsurgical skin tightening procedure that heats the deeper layers of skin to encourage production of collagen and elastin, proteins that make skin firm and plump.
Is This A Scam?
What gua sha and jade rolling won’t do is promote collagen production or erase wrinkles, Dr. Allawh said. “To date, there is little evidence to support this.”
Additionally, other non-CB1 receptor mechanisms of CBD have been proposed, among them its agonism at serotonin 1A receptor (or 5-TH1A), vanilloid receptor 1 (TRPV1) and adenosine A2A receptors [18,19]. The complex physiological and pharmacological mechanisms and interaction of CBD with the endocannabinoid system and other molecular targets are extensively reviewed by McPartland et al. . These data may help explain some of the observed CBD effects including analgesic, anti-inflammatory, anti-anxiety and anti-psychotic activity . The combination of THC and CBD with other phytocannabinoids and other components, such as terpenoids and flavonoids, in cannabis may have a synergistic effect on pain treatment [22,23].
2. Role of Cannabinoids in Inflammation and Pain
Lipid nanoparticles in a solid particle matrix are produced from oil/water emulsions by simply replacing the liquid lipid (oil) with a solid lipid, i.e., one that is solid at body temperature. First generation analogues, produced from a solid lipid only, are named solid lipid nanoparticles. The second generation of nanostructured lipid carrier (NLC) particles are produced from a blend of a solid lipid and a liquid lipid, in which the partially crystallized lipid particles, with mean radii ≤ 100 nm, are dispersed in an aqueous phase containing one or more emulsifiers . NLC can be considered suitable carrier systems for THC and CBD because they make use of solid particle matrices instead of fluid matrices, such as emulsions and liposomes, meaning that NLC can better host substances and protect them from degradation. The solid particle matrix is also able to slow the diffusion of THC from inside the particle to the particle surface.
3.5.2. Polymeric Carriers
A proprietary CBD nanotherapeutic formulation (CTX01) for subcutaneous administration is being developed by Cardiol Therapeutics (Oakville, ON, Canada) the treatment of heart failure with preserved ejection fraction. Preclinical studies are currently under way (Cardiol web site) .