Director of the Brain Institute of the University of Utah, Deborah Yurgelun-Todd is “testing the analgesic effects of orally-dosed Cannabidiol on subjects with non-cancer pain.”
“Among CBD products purchased online, a wide range of CBD concentrations was found, consistent with the lack of accepted dose. Of products tested, 26 percent contained less CBD than labeled which could negate any potential clinical response. The over labeling of CBD products in this study is similar in magnitude to levels that triggered warning letters to 14 businesses in 2015-2016 from the U.S. Food and Drug Administration (e.g., Actual CBD content was negligible or less than 1 percent of the labeled content).”
And if you’re thinking of buying a bottle from Amazon or any other online source, remember this warning.
Marijuana only became illegal in the U.S. with the passage of the Controlled Substances Act in 1970, though regulation rumblings had been growing since the 1920s.
Pharmaceutical-grade CBD oil, or cannabidiol oil, is derived from the cannabis plant and can be packaged in a variety of forms: gel cap, cream, oil, salve, tincture, or maybe even a transdermal or skin patch. Its effect is not the same as smoking and doesn’t produce the same cloudy euphoria and munchie giggles as the roll-your-own stuff you might have enjoyed in your college days.
These studies have passed the rigorous rules of the Institutional Review Boards of the respective university.
Despite the fact that @heavers_said, “It’s my saving grace” and Vitamin Weed author Dr. Michele Ross, Ph.D. swears by the stuff, there is not a lot of authoritative clinical evidence for its effectiveness.
In June, the FDA made history when it approved the use of a purified form of CBD oil to treat seizures in two “rare and severe” forms of epilepsy. Dr. Orrin Devinsky, director of NYU Langone Epilepsy Center, noted at the time, “It’s very important to highlight that the drug used in this study, cannabidiol, was…purified to 99 percent purity.”
And it’s nothing to fool with. “There is evidence,” according to Dr. Tomar Singer, director of reproductive endocrinology and infertility at the Lenox Hill Hospital in New York City, “that cannabis oil or cannabidiol can decrease fertility by affecting ovulation and implantation.”
In a 2017 study, the authors showed that drugs stimulating CB1 and CB2 receptors contributed to decreased proliferation and growth of endometrial tissue and its breakdown or what we call apoptosis .
Currently, the only federally legal way to use CBD for endometriosis is by taking CBD oil and/or cream. This way, you can both support your endocannabinoid system and target localized pain.
Dr. Ethan Russo, a neuroscientist and passionate proponent of the entourage effect, underlines the importance of whole-plant cannabis medicine as a treatment for endometriosis and other conditions.
Animal and preclinical human studies have shown that CBD has anti-inflammatory and analgesic properties. These effects may be useful in targeting pain that is difficult to treat, such as the one triggered by endometriosis.
Final Thoughts on CBD and Endometriosis
The goal of successful CBD dosage for endometriosis is to find the amount that gets you maximum effects with few side effects.
When you take CBD oil, gummies, or capsules, they target EM symptoms from within, which is great for symptom control and reaching the underlying cause.
Cannabis dosages always start from low amounts and take time to gauge the effective dosage for each individual. Doctors will start you on a medication they believe will work best for you and then titrate the dose to adjust it to the severity of your symptoms and your individual body chemistry.
A lot of women with endometriosis combine two forms of CBD oil — oral and topical.
It’s worth noting that throughout human history, plants have been used medicinally. Synthetic drugs were developed later, but many of them are based directly or indirectly on plant-based chemicals.
If you’re not familiar with the abbreviation, it’s referring to cannabidiol, one of the many molecules found in marijuana and hemp. 1 The hemp-derived version is what I tried and is legal in most states. 2 Unlike its cousin THC, it does not have any psychoactive effects and won’t get you high. It is, however, supposedly helpful in fighting inflammation and chronic pain. 3
First, I weighed my options
I didn’t have to take any ibuprofen the first couple days I tried it — that is a very noticeable improvement. My pain is usually constant during this time. When I did feel my cramps resurfacing, I found that taking CBD, which acts on the body’s endocannabinoid system, seemed to increase the speed and effectiveness of the single ibuprofen I did take. 4
The real test
The start of my period is brutal. My pain is so bad on the first day of my menstrual cycle that I will throw up if I don’t have ibuprofen at the ready. That is not an exaggeration. It is why you will find loose ibuprofen in nearly every thing I own: camping bags, purses, my bedside lamp, random jacket pockets.